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My car is restricted due to its license plate number on every Tuesday, this morning, a Tuesday morning, September 8, 2026, after breakfast, I took a taxi to send my boy to school, then I walked outdoors 1.6 miles, and then I came home and didn’t feel any desire to defecate, so I sat down at my desk on my computer, about 3 hours later, I felt a little bit of desire to defecate, but I knew it would be difficult to defecate if I directly went to the bathroom, so I used my solution to constipation, stood up reading CNN news on my phone, 29 minutes (12:31 - 13:00 AM China time) later, I had to rush to the bathroom to defecate.

This morning, a Monday morning, September 7, 2026, after breakfast, I drove my boy to school, then I walked outdoors 1.8 miles, and then I came home and didn’t feel any desire to defecate, so I sat down at my desk on my computer, about two hours later, I felt a little bit of desire to defecate, but I knew it would be difficult to defecate if I directly went to the bathroom, so I used my solution to constipation, stood up reading CNN news on my phone, 5 minutes (10:38 - 10:43 AM China time) later, I had to rush to the bathroom to defecate.

This morning, a Sunday morning, September 6, 2026, after breakfast, I walked outdoors 2.2 miles, and then I came home and didn’t feel any desire to defecate, so I sat down at my desk on my computer, about two hours later, I felt a little bit of desire to defecate, but I knew it would be difficult to defecate if I directly went to the bathroom, so I used my solution to constipation, stood up reading CNN news on my phone, 5 minutes (11:28 - 11:33 AM China time) later, I had to rush to the bathroom to defecate.

I have been to the doctor 3 times over the last month. It all started with right side/back pain and constipation. I then went back for chest tightness and left arm pain. Did all of the heart tests and came out ok. So I started taking sertraline(Zoloft) doctor thought it was anxiety induced. During that time I was on a 4 pill sample of Linzess 145mcg which seemed to work but cause very watery and frequent diarrhea. It also helped with the pain. Two days after the sample the pain came back so I took MiraLAX for a week. Finally after that didn’t work for six days I called and they prescribed me more Linzess at 75 mcg. I’m 3 days in and have had 4 to 5 watery bowel movements a day. Some right side fullness. Left pain has decreased but still there occasionally. I have lost 11 pounds over this month. I am 19. Do you all think I have IBS-c? Or do I have type 2 diabetes? Not sure what to do just very anxious. Please and recommendations or personal experiences.

Pleased that ibspatient.org was involved in examining patient perspectives posted online on social media platforms and forums, exploring the perspectives and experiences of IBS-C patients who report using FDA-approved therapies. pubmed.ncbi.nlm.nih.gov/4269… @NGMJournal — @IBSpatient Sep 5, 2026View the full article

This morning, a Saturday morning, September 5, 2026, after breakfast, I walked outdoors 1.7 miles, and then I came home and didn’t feel any desire to defecate, so I sat down at my desk on my computer, about two hours later, I felt a little bit of desire to defecate, but I knew it would be difficult to defecate if I directly went to the bathroom, so I used my solution to constipation, stood up reading CNN news on my phone, 5 minutes (10:56 - 11:01 AM China time) later, I had to rush to the bathroom to defecate.

Candida overgrowth may contribute to symptoms ranging from IBS and recurrent vaginitis to brain fog and chronic fatigue. Dean Mitchell, MD, author of "Conquering Candida", discusses how antibiotics, PPIs, stress and microbiome disruption can promote Candida overgrowth, as well as his approach to treatment using diet, antifungals, vitamin therapy and sublingual Candida immunotherapy. He also explores the limitations of Candida testing and the importance of restoring a diverse microbiome on The Perfect Stool Podcast with host Lindsey Parsons, EdD. Listen through Spotify link below: https://open.spotify.com/show/39MQQm9fZbMfcmOGtw0nKa?si=c7ded22a4c334d29 or find various podcast player links at: https://linktr.ee/theperfectstoolpodcast

Neurogastroenterol Motil. 2026 Sep;38(9):e70432. doi: 10.1111/nmo.70432. ABSTRACT BACKGROUND: Irritable bowel syndrome with constipation (IBS-C) is a common disorder of gut-brain interaction that significantly impairs quality of life. Although multiple US Food and Drug Administration (FDA)-approved medications have demonstrated efficacy in randomized controlled trials, less is known about patients' real-world experiences and factors influencing treatment decisions. Here, we conducted social media netnography-a qualitative approach for examining patient perspectives posted online on social media platforms and e-health forums, exploring the perspectives and experiences of IBS-C patients who report using FDA-approved therapies. METHODS: We examined publicly available posts from X and online health e-forums (Reddit, WebMD, ibspatient.org) made between 9/19/2007 and 9/12/2024. Overall, 7328 relevant posts referencing FDA-approved IBS-C medications (linaclotide, lubiprostone, plecanatide, tegaserod, tenapanor) were included. We employed qualitative (open coding) and quantitative approaches (natural language processing and artificial intelligence) to analyze the posts. RESULTS: Four major themes emerged: (i) perceived medication efficacy; (ii) treatment-related burden; (iii) intentional non-adherence; and (iv) barriers to adherence. Patients described heterogeneous efficacy, ranging from meaningful symptom relief to limited or no benefit. Patients discussed the biopsychosocial burden of IBS-C medications (e.g., nausea, frustration, social anxiety from potential diarrheal side effects), highlighting various barriers to adherence. Barriers such as cost, insurance coverage, and personal beliefs also influenced decisions, often prompting discontinuation, dose adjustments, or pursuit of alternative therapies. CONCLUSIONS: Social media provides unique insights into IBS-C patients' real-world experiences with FDA-approved therapies. Findings highlight variability in efficacy, biopsychosocial impacts, and adherence challenges, underscoring the need for shared decision making and proactive management of barriers to optimize outcomes. Key Points Qualitative analysis of 7328 social media and e-forum posts captured candid, real-world perspectives from patients with IBS-C, revealing variability in perceived medication efficacy, treatment-related burden, intentional non-adherence, and barriers to adherence. NLP and AI methods demonstrated that the large language model reliably classified patient posts, achieving performance comparable to human annotators and supporting its use for larger-scale analyses of patient experiences. Given the complexity of patients' treatment experiences, these findings underscore the importance of shared decision-making and proactive management of treatment barriers to support personalized care and improved patient outcomes. PMID:42694017 | DOI:10.1111/nmo.70432 View the full article

This morning, a Friday morning, September 4, 2026, after breakfast, I drove my boy to school, then I walked outdoors 1.6 miles, and then I came home and didn’t feel any desire to defecate, so I sat down at my desk on my computer, about two hours later, I felt a little bit of desire to defecate, but I knew it would be difficult to defecate if I directly went to the bathroom, so I used my solution to constipation, stood up reading CNN news on my phone, 4 minutes (10:48 - 10:52 AM China time) later, I had to rush to the bathroom to defecate.

I am sorry to hear that you were taken advantage of. Is this an individual? Can you share how this happened?

Nobody deal with pharma flex the guy is a scammer and he will take your money, I got scammed by him I’m spreading awareness so nobody else gets robbed

This morning, a Thursday morning, September 3, 2026, after breakfast, I drove my boy to school, then I walked outdoors 1.6 miles, and then I came home and didn’t feel any desire to defecate, so I sat down at my desk on my computer, about two hours later, I felt a little bit of desire to dedicate,but I knew it would be difficult to defecate if I directly went to the bathroom, so I used my solution to constipation, stood up reading CNN news on my phone, 3 minutes (11:24 - 11:26 AM China time) later, I had to rush to the bathroom to defecate.

I said my solution to constipation is a perfect cure for constipation, almost all people here don’t trust me, some asked me to show the evidence. The first piece of evidence: this solution has completely solved my problem of six years of chronic constipation. Other about 2 dozen pieces of evidence: this solution has completely solved the problem of chronic constipation for about two dozen people around me, including one with more than 45 years of constipation and one with the worst constipation (sometimes not having a bowel movement in 11 days). These pieces of evidence show that it works 100% for everybody who is willing to try it. I and the other about two dozen people around me who tried my solution are Chinese, it looks like that you don’t trust me and the other about two dozen Chinese. Now I have found three more pieces of evidence: in June 2025, I posted this solution on Mayo Clinic Connect, I encouraged people there to try it and instructed three people how to use it, attached please find the three screenshots of the emails Mayo Clinic Connect sent to me, these emails showed it worked for all the three people whom I instructed, they also showed it works 100%. I think these three people are Americans. Even if you don’t trust me and other about two dozen Chinese, I think, you should trust these three Americans, you can also go to Mayo Clinic Connect to verify what these three people said and the results of my solution for these three people.

Front Med (Lausanne). 2026 Aug 18;13:1900112. doi: 10.3389/fmed.2026.1900112. eCollection 2026. ABSTRACT INRODUCTION: Evidence for probiotics in irritable bowel syndrome remains heterogeneous, although real-world use is common in Chinese gastroenterology practice. This study evaluated whether initiation of multi-strain probiotics, compared with contemporary standard care without probiotics, was associated with clinically meaningful symptom and quality-of-life improvement in adults with diarrhoea-predominant or mixed irritable bowel syndrome. METHODS: This single-centre retrospective real-world cohort study identified adults with Rome IV IBS-D or IBS-M managed between January 2022 and December 2024 from electronic health records. A new-user design with a symmetrical 14-day landmark was used. After prespecified exclusions, 287 patients comprised the full analytic set, including 122 probiotic initiators and 165 non-users. One-to-one nearest-neighbour propensity score matching yielded 75 matched pairs. Outcomes were assessed at 4-6 and 8-12 weeks, with change in IBS Symptom Severity Score from baseline to 8-12 weeks as the primary endpoint. RESULTS: In the matched cohort, probiotic initiation was associated with a greater reduction in IBS-SSS than standard care at 8-12 weeks, with mean changes of -95 versus -60 points and a mean difference of -35 points (95% CI: -50 to -20; p = 0.001). IBS-SSS response occurred more frequently with probiotics than with non-use (62.7% versus 44.0%), as did pain response (58.7% versus 40.0%) and adequate relief (54.7% versus 38.7%). IBS-QOL improved by 16.0 versus 8.0 points, and IBS-QOL minimal clinically important difference response was more frequent with probiotics (53.3% versus 34.7%). Adverse events were infrequent and similar between groups (16.0% versus 13.3%). Treatment escalation occurred less often with probiotics (24.0% versus 40.0%). DISCUSSION: In routine Chinese hospital care, initiation of multi-strain probiotics was associated with earlier and clinically meaningful symptom improvement, better disease-specific quality of life, and fewer treatment escalations among adults with IBS-D or IBS-M, without an apparent excess of adverse events. PMID:42682476 | PMC:PMC13529527 | DOI:10.3389/fmed.2026.1900112 View the full article

This morning, a Wednesday morning, September 2, 2026, after breakfast, I drove my boy to school, then I walked outdoors 1.5 miles, and then I came home and felt a little bit of desire to defecate, but I knew it would be difficult to defecate if I directly went to the bathroom, so I used my solution to constipation, stood up reading CNN news on my phone, 12 minutes (8:59 - 9:11 AM China time) later, I had to rush to the bathroom to defecate.

What happens when the stress of being a first responder doesn’t just stay in your head but starts showing up in your gut? Today, we’re joined by Police Chief Michael Assad Jr. of the Rochester, Massachusetts Police Department for an honest conversation about the often-overlooked connection between first responder stress, gut health, IBS, and nutrition. From high-pressure calls and long shifts to those unexpected “code brown” moments, chronic stress can take a serious toll on the digestive system. We’ll talk about recognizing those warning signs, why gut health deserves more attention in the first responder community, and how nutrition, stress management and everyday habits can play a role in feeling better and performing at your best. This is a conversation about stress, resilience, and taking care of the part of your body that may be trying to tell you it’s time to slow down and pay attention. We share practical ways to build a culture where officers can recover from adrenaline, fuel better on shift, and get support without stigma. • why shift work and disrupted routines can trigger IBS symptoms • the “SHIT” acronym: shift work, high octane habits, irregular nutrition, tactical stress • how energy drinks, dehydration, and gas station food can backfire fast • simple leadership moves that normalize wellness and real help seeking • fitness incentives, workout on duty, and building a wellness room • on scene tools like box breathing and diaphragmatic breathing • gentle diet cleanup basics: adjusting caffeine, alcohol, hydration, and fiber, per tolerance • nicotine pouches and stress habits that can worsen gut symptoms • when to see a doctor and what red flags to watch for • why a clear diagnosis can lower stress and improve symptoms Don't forget to subscribe, rate, and leave us a comment. You can also follow us on social media @TheGutHealthPodcast, where we'd love for you to share your thoughts, questions, and experiences. This podcast was sponsored by Ardelyx. Sorry for Kate’s raspy voice, she’s just getting over a cold! And a big thank-you to Megan for holding down the fort. ❤️ References: Hartley TA, Violanti JM, Mnatsakanova A, Andrew ME, Burchfiel CM. Military experience and levels of stress and coping in police officers. Int J Emerg Ment Health. 2013;15(4):229-39. PMID: 24707586; PMCID: PMC4734366. Shin A, Xu H, Imperiale TF. The Prevalence, Humanistic Burden, and Health Care Impact of Irritable Bowel Syndrome Among United States Veterans. Clin Gastroenterol Hepatol. 2023 Apr;21(4):1061-1069.e1. doi: 10.1016/j.cgh.2022.08.005. Epub 2022 Aug 11. PMID: 35964894; PMCID: PMC9918609. Demo of diaphragmatic breathing. Learn more about Kate and Dr. Riehl: Website: www.katescarlata.com and www.drriehl.com Instagram: @katescarlata @drriehl and @theguthealthpodcast Order Kate and Dr. Riehl's book, Mind Your Gut: The Science-Based, Whole-body Guide to Living Well with IBS. The information included in this podcast is not a substitute for professional medical advice, examination, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider before starting any new treatment or making changes to existing treatment.

Psychological and social factors that contribute to disordered eating, especially in relation to IBS and health misinformation. I cover how this can build up, including personality traits, social media influence, and practical strategies for managing food-related anxiety. Why diet layering is more difficult in IBS Risk factors for orthorexia and disordered eating in IBS Links Ep 43 - ARFID in IBS Ep 159 - with Anne Richardson - The Eating Disorder Nutritionist Buy my book - Inside Knowledge for people with IBS & SIBO (find it on Amazon) Get free weekly IBS & SIBO emails - https://mailchi.mp/goodnessme-nutrition.com/h6acndd1bs Work with me 3 month Gut Reset - https://www.goodnessme-nutrition.com/consultations/ Ready for your gut reset? 🌍 I work with clients worldwide, providing remote consultations and a wealth of educational resources for IBS and SIBO. Instagram - @goodnessme_nutrition The information in this podcast is not medical advice and is not designed to treat, diagnose or provide personalised health advice. This podcast content is information only and any changes you make are at the user's own risk. Please consult with your doctor or healthcare provider before implementing any new treatment. View the full article

My car is restricted due to its license plate number on every Tuesday, this morning, a Tuesday morning, September 1, 2026, the student summer break is over, after breakfast, I took a taxi to send my boy to school, then I walked outdoors 1.7 miles, and then I came home and felt a little bit of desire to defecate, but I knew it would be difficult to defecate if I directly went to the bathroom, so I used my solution to constipation, stood up reading CNN news on my phone, 4 minutes (8:41 - 8:45 AM China time) later, I had to rush to the bathroom to defecate.

Scientists uncover microbiome signaling system that could open new paths for IBS-related constipation Mayo Clinic News Network Mayo Clinic researchers have discovered that chemical signals produced by gut bacteria work together to control intestinal movement. One bacterial signal helps set the intestines in motion, while another primes gut cells to respond more strongly, amplifying the effect. The research expands scientists' understanding of how the gut microbiome communicates with the body, moving beyond the traditional focus on individual bacteria or bacterial molecules. The findings, published in the Proceedings of the National Academy of Sciences, point to a potential new direction for microbiome-based treatments: restoring combinations of microbial signals rather than targeting a single microbe or molecule. The strategy could have implications for constipation-predominant irritable bowel syndrome, a chronic condition marked by abdominal pain and constipation. "The gut microbiome is made up of trillions of microbes producing a vast array of chemical messages that interact with cells throughout the digestive tract," says Purna Kashyap, M.B.B.S., a Mayo Clinic gastroenterologist, director of the Mayo Clinic Microbiomics Program and a senior author of the study. "Deciphering how those signals work in combination gives us a much more precise picture of what is disrupted in disease and what would need to be restored to recover normal function." How bacterial signals work in combinationResearchers focused on two bacterial molecules: hypoxanthine and butyrate. Earlier Mayo Clinic research found lower levels of both in patients with constipation-predominant irritable bowel syndrome. That finding led researchers to a deeper question: How do these molecules affect intestinal movement? In the new study, the researchers found that hypoxanthine prompts specialized cells lining the intestine to release serotonin, a chemical messenger that helps move food through the digestive tract. Butyrate works differently. It primes the cells to respond more strongly to hypoxanthine, amplifying the effect. These specialized cells, called enterochromaffin cells, serve as hubs where different microbial signals come together. They help the gut receive and respond to multiple chemical messages at once. Researchers followed that chain of events from what happens inside a single gut cell to how contents move through the intestines. They used laboratory-grown intestinal cells, miniature gut models called organoids, intestinal tissue and genetically altered bacteria to piece together each part of the process. Gianrico Farrugia, M.D., president and CEO of Mayo Clinic and a co-author of the study, is a gastroenterologist whose research has focused on the mechanisms that control gastrointestinal function. "We have an opportunity to move beyond managing the consequences of disease and toward restoring function for patients," Dr. Farrugia says. "That starts with answering the unanswered questions we see in our patients and following the biology until we understand the mechanism. With that depth of understanding, we can uncover new possibilities for treatment and ultimately advance new cures." What's next Researchers next want to determine whether identifying combinations of microbial signals that are altered in individual patients could eventually help guide treatment. Future research will explore whether restoring complementary signals can improve intestinal movement, with the longer-term goal of developing more precisely targeted microbiome-based therapies. The research was supported by the National Institutes of Health, Mayo Clinic Center for Individualized Medicine, Mayo Clinic Microbiome Program and other organizations. One or more of the investigators is an inventor of technology related to this research. For a complete list of authors, disclosures and funding, review the study. View the full article

Hi can anyone help I have had IBS for 40years had all the tests and did the food maps etc but nothing helps me as I am in pain daily and feel I have no life I take dihydrocodeine for the pain and that helps sometimes I have had a lot of operations and endometriosis twice and have sensitive stomach and helocobactor they say scared tissue does impact me not sure I am under a lot of stress the past year due to ill parents so this will impact the IBS eh I am now lost on what else I can do to get rid of this pain any ideas Thank you xx

Gastroenterologists Reveal Why So Many People Over 50 Are Constipated Prevention Almost everyone experiences the occasional bout of constipation. But some people feel backed up more frequently than others, whether that’s because of an existing gastrointestinal disorder, taking certain medications, or age. That’s right—you’re more likely to feel constipated as you get older. So here, we’re taking a look at why constipation becomes more common after 50. “Constipation becomes more common with age, although getting older does not automatically mean getting constipated,” says Douglas Weine, M.D., a gastroenterologist at Red Bank Gastroenterology in Red Bank, N.J. Instead, there are certain situations that are more common in people over 50 than in younger folks that make constipation more likely to occur. View the full article

On this episode of the Gut Matters podcast, co-hosts Johannah Ruddy and Dr. Andrea Shin are joined by Dr. Tiffany Duffing, a licensed clinical psychologist and US Army veteran, and Mike Wynn, director of the Quell Foundation's First Responder Resilience Project, to explore the gut-brain connection in veterans and first responders. The conversation covers how chronic stress, PTSD, and hypervigilance can drive IBS symptoms, particularly constipation, through top-down and bottom-up nervous system dysregulation. The guests share evidence-based interventions like diaphragmatic breathing, gut-directed CBT, and clinical hypnosis, while Mike offers a candid look at the cultural barriers to seeking care in law enforcement and the Quell Foundation's video-based mental health training programs now rolling out to agencies nationwide. Gut Matters is produced by BloodStream Media and made possible by Ardelyx. Content Producer: Mishu Nitulescu. At Ardelyx®, we are dedicated to improving the lives of patients by discovering, developing, and commercializing first-in-class medicines that advance care to patients with unmet medical need. Learn more about us at Ardelyx.com Transparency Statement: Gut Matters: Discoveries and Innovations is produced by Believe Limited and made possible by Ardelyx®. The following Ardelyx®-supported program is intended for informational and educational purposes only and is not intended as medical advice. Please speak with your healthcare professional before making any medical decisions. View the full article

This morning, a Monday morning, August 31, 2026, the student summer break is over, after breakfast, I drove my boy to school, then I walked outdoors 1.6 miles, and then I came home and felt a little bit of desire to dedicate, but I knew it would be difficult to defecate if I directly went to the bathroom, so I used my solution to constipation, stood up reading CNN news on my phone, 10 minutes (9:25 - 9:35 AM China time) later, I had to rush to the bathroom to defecate. Look, with my scientific discovery, constipation isn’t a problem for me anymore, and I’m pretty sure that it will not be a problem anymore for anyone who can stand up on this planet after this discovery gets published, provided they are willing to try my solution and they have full confidence in my solution, standing until wanting to defecate.

This morning, a Monday morning, August 31, 2026, the student summer break is over, after breakfast, I drove my boy to school, then I walked outdoors 1.6 miles, and then I came home and felt a little bit of desire to dedicate, but I knew it would be difficult to defecate if I directly went to the bathroom, so I used my solution to constipation, stood up reading CNN news on my phone, 10 minutes (9:25 - 9:35 AM China time) later, I had to rush to the bathroom to defecate. Look, with my scientific discovery, constipation isn’t a problem for me anymore, and I’m pretty sure that it will not be a problem anymore for anyone who can stand up on this planet after this discovery gets published, provided they are willing to try my solution and they have full confidence in my solution, standing until wanting to defecate.