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  3. RT @MASTprogram: Closing out the 5th #GutMicrobiome conference with .@MarkPimentelMD who shares the up-and-coming advancements in microbiome sampling, testing and treatment. And the failures we’ve seen this year. (Feed generated with FetchRSS) View the full article
  4. RT @robinberlinrd: .@AliRezaieMD discusses symptoms associated with #SIBO. Diagnosis with Lactulose Breath test and treatment with antibiotics. Three Pillars: Diagnose, Treat, follow up with Low Fermentation Diet. #GutMicrobiome (Feed generated with FetchRSS) View the full article
  5. Jeffrey Roberts

    Ibs-d how often?

    It sounds like IBS; however, those symptoms are similar for other illnesses too. IBS isn't something that you should try and diagnose yourself. I doctor is trained to look for clues and redflags indicating something else might be going on.
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  7. Related Articles Elucidating the putative link between prefrontal neurotransmission, functional connectivity, and affective symptoms in irritable bowel syndrome. Sci Rep. 2019 Sep 19;9(1):13590 Authors: Icenhour A, Tapper S, Bednarska O, Witt ST, Tisell A, Lundberg P, Elsenbruch S, Walter S Abstract Altered neural mechanisms are well-acknowledged in irritable bowel syndrome (IBS), a disorder of brain-gut-communication highly comorbid with anxiety and depression. As a key hub in corticolimbic inhibition, medial prefrontal cortex (mPFC) may be involved in disturbed emotion regulation in IBS. However, aberrant mPFC excitatory and inhibitory neurotransmission potentially contributing to psychological symptoms in IBS remains unknown. Using quantitative magnetic resonance spectroscopy (qMRS), we compared mPFC glutamate + glutamine (Glx) and γ-aminobutyric acid (GABA+) concentrations in 64 women with IBS and 32 age-matched healthy women (HCs) and investigated their association with anxiety and depression in correlational and subgroup analyses. Applying functional magnetic resonance imaging (fMRI), we explored whether altered neurotransmission was paralleled by aberrant mPFC resting-state functional connectivity (FC). IBS patients did not differ from HCs with respect to mPFC GABA+ or Glx levels. Anxiety was positively associated with mPFC GABA+ concentrations in IBS, whereas Glx was unrelated to psychological or gastrointestinal symptoms. Subgroup comparisons of patients with high or low anxiety symptom severity and HCs revealed increased GABA+ in patients with high symptom severity, and lower mPFC FC with adjacent anterior cingulate cortex (ACC), a crucial region of emotion modulation. Our findings provide novel evidence that altered prefrontal inhibitory neurotransmission may be linked to anxiety in IBS. PMID: 31537890 [PubMed - in process] View the full article
  8. FDA approves new packaging limits for loperamide HealioThe FDA has approved new package size and type limits for the over-the-counter, brand-name tablet and capsule forms of loperamide, a diarrhea drug, ... View the full article
  9. Hmm, I think I’m asking both! Thanks so much for that. I tend to have one or maximum 2 movements, that start with cramps. it was happening once a week but then more sporadic, between 1-4 weeks. Also tends to be within 2 hours of having food. Does it sound like IBS to you?
  10. Jeffrey Roberts

    Ibs-d how often?

    So you are asking when you have D, how many times do you go in a row? or How often do you get days in a row that you have D? IBS can be best considered as a change in bowel habit lasting at least 3 months. You would have to have D (or C) for a good portion of those months. When you have D, it would be 3-10 times over a day. Three isn't a magic number. Some people have constipation (C) that changes into D so they go multiple times over a day. Does that help you to understand it better?
  11. For those with ibs-d how often do you get the diarrhea. I’m finding it’s intermittent, and it’s not a lot of times I’m needing to go, I will get cramps, followed by one bowel movement of diarrhea and that’s it. A week or 2 later will happen again. Does this sound like ibs?
  12. Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity. JCI Insight. 2019 Sep 19;: Authors: Castro J, Harrington AM, Lieu T, Garcia-Caraballo S, Maddern J, Schober G, O'Donnell T, Grundy L, Lumsden AL, Miller PE, Ghetti A, Steinhoff MS, Poole DP, Dong X, Chang L, Bunnett NW, Brierley SM Abstract Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. Whilst pain arises from both the skin and viscera, we investigated whether pruritogenic irritant mechanisms also function within visceral pathways. We show that subsets of colon-innervating sensory neurons in mice express, either individually or in combination, the pruritogenic receptors Tgr5 and the Mas-gene-related G protein-coupled receptors, Mrgpra3 and Mrgpra11. Agonists of these receptors activated subsets of colonic sensory neurons and evoked colonic afferent mechanical hypersensitivity via a TRPA1-dependent mechanism. In vivo intra-colonic administration of individual TGR5, MRGPRA3, or MRGPRC11 agonists induced pronounced visceral hypersensitivity to colorectal distension. Co-administration of these agonists as an 'itch cocktail' augmented hypersensitivity to colorectal distension and changed mouse behaviour. These irritant mechanisms were maintained and enhanced in a model of chronic visceral hypersensitivity relevant to irritable bowel syndrome. Neurons from human dorsal root ganglia also expressed TGR5 as well as the human ortholog MRGPRX1 and showed increased responsiveness to pruritogenic agonists in pathological states. These data support the existence of an irritant-sensing system in the colon that is a visceral representation of the itch pathways found in skin, thereby contributing to sensory disturbances accompanying common intestinal disorders. PMID: 31536477 [PubMed - as supplied by publisher] View the full article
  13. Electrocolonography: Non-invasive detection of colonic cyclic motor activity from multielectrode body surface recordings. IEEE Trans Biomed Eng. 2019 Sep 16;: Authors: Erickson JC, Bruce LE, Taylor A, Richman J, Higgins C, Wells CI, O'Grady G Abstract OBJECTIVE: This work validates a novel non-invasive method to identify periods of cyclic motor activity in the colon using multichannel skin-surface electrical recordings on the lower abdominal region, termed electrocolonography (EColG). METHODS: EColG recordings were made from 21 human subjects during a 3 hr meal-response study. A signal processing pipeline based on Continuous Wavelet Transform time-frequency analysis was used to quantify the spectral power in the colonic frequency band ( ≈ 2-6 cycles per minute; cpm) during the fasted and fed states. RESULTS: EColG identified a substantial 7.4 ± 3.5 × maximum transient increase in motor activity in the fed state versus the fasted state, as well as a 38.3 ± 16.7% sustained spectral power increase in the colonic frequency band. The dominant frequency was 3.61 ± 0.49 cpm, with activity localized primarily in the infraumbilical region near the (recto-)sigmoid colon segments. CONCLUSION: The colonic meal-responses identified with EColG were closely concordant with rectosigmoid motor activity previously characterized by intracolonic high-resolution manometry. This study is the first to demonstrate that body surface electrical recordings can properly identify rhythmic colonic activity stimulated by food intake. SIGNIFICANCE: The new EColG technique is inexpensive, portable, and presents the opportunity for reliably measuring colonic motility by noninvasive means. We anticipate that EColG could be applied to monitor the progression of postoperative ileus, and more precisely diagnose abnormal colonic motor patterns in patients suffering from common functional disorders, such as irritable bowel syndrome. PMID: 31535980 [PubMed - as supplied by publisher] View the full article
  14. Anxiety and nausea: What is the link? Medical News TodayAnxiety can cause a range of physical symptoms. Gastrointestinal symptoms, such as nausea, are particularly common. Discover the link between anxiety and ... View the full article
  15. RT @FodyFoods: Tune in to our first ever #IGTV episode with @KateScarlata_RD where she explains a FODMAP Gentle Diet, term coined by @monashfodmap. https://pos.li/2d9l4m #FodyFactFridays #FodyFactFridayswithKateScarlata (Feed generated with FetchRSS) View the full article
  16. 14 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: irritable bowel syndrome These pubmed results were generated on 2019/09/19 PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. View the full article
  17. 14 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: irritable bowel syndrome These pubmed results were generated on 2019/09/19 PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. View the full article
  18. Our annual course FOOD: main course to digestive health starts friday!! From 70 delegates in 2016 to 200 this year! @umichmedicine (Feed generated with FetchRSS) View the full article
  19. Obesity linked with chronic diarrhea HealioPatients with obesity are at greater risk for chronic diarrhea, and the association grew stronger as BMI increased, according to the results of a nationally ... View the full article
  20. The Link Between The Gut, Food Allergies and IBS Longevity LIVEWe are what we eat – if there's one thing you need to understand about nutrition and food allergies, it's this. In this day and age, we face a big increase in ... View the full article
  21. IBS med Zelnorm relaunches more than a decade after disastrous recall—does it have a shot? FiercePharmaZelnorm was a steady seller for Novartis before cardiovascular red flags led to the IBS med's collapse. Now—more than a decade after its recall and with new ... View the full article
  22. Related Articles Evaluation of Physiological, Psychological, and Lifestyle Factors Associated with Premature Hair Graying. Int J Trichology. 2019 Jul-Aug;11(4):153-158 Authors: Thompson KG, Marchitto MC, Ly BCK, Chien AL Abstract Background: Canities, or hair graying, is believed to be driven by the cytotoxic effect of reactive oxygen species on follicular melanocytes, thus raising the concern that premature hair graying (PHG) may represent an outward sign of systemic oxidative stress. Objective: This study aimed to identify the physiological, psychological, and lifestyle factors associated with PHG (defined as graying at age ≤30 years) in men and women. Materials and Methods: Data from 467 participants (female = 354 and male = 113; age: 18-77 years) were collected and analyzed, including demographic information, medical history, family history, supplement intake, and lifestyle factors. Results: PHG was found to be significantly associated with a history of PHG in the mother, P<0.001, odds ratio (OR) = 3.165; father, P<0.001, OR = 5.166; maternal grandparent, P= 0.002, OR = 2.442; paternal grandparent, P= 0.007, OR = 2.369; and siblings, P<0.001, OR = 3.125. PHG was significantly associated with iron deficiency (P = 0.026, OR = 1.751) and family history of depression (P = 0.012, OR = 1.603), while herpes simplex virus infection (P = 0.004, OR = 0.367) and smoking history (P = 0.003) demonstrated significant negative associations. In Caucasians only (n = 306), in addition to these trends, irritable bowel syndrome was also significantly associated with PHG (P = 0.010, OR = 2.753). In Asians only (n = 75), history of heart disease in a first-degree relative (P = 0.038) was significantly associated with PHG. Limitations: As a survey study, the findings may be subject to recall bias. Conclusions: Important associations exist between PHG and family history of PHG, psychiatric history, supplement use, and vitamin deficiencies, providing insight into the pathophysiology and potential comorbidities of PHG. PMID: 31523106 [PubMed] View the full article
  23. Cognitive behavioral therapy could lead to long-term benefits for IBS Mental DailyIn a past study by researchers at the University of Southampton, they demonstrated how patients with refractory irritable bowel syndrome (IBS) may find relief of ... View the full article
  24. A colostomy bag collects fecal waste from the digestive tract after a person has a colostomy. Learn more about the different types and life with a colostomy bag here. View the full article
  25. RT @drjshapiro: #IBS #ACG ⁦@AmCollegeGastro⁩ Love this online patient checklist for prior IBS treatments. So many doctors are recreating the wheel, and it’s new and here for the taking. I’m taking it! ⁦@bcm_gihep⁩ (Feed generated with FetchRSS) View the full article
  26. Hi Madeline, I was around the same age as you when I was first diagnosed with IBS. Kind of miserable. It certainly did influence my life, but I went on to finish school, college and a graduate degree. I've had a career, family and travel. You can and will get past this. I totally get how anxious and depressed you must be feeling. It does feel kind of hopeless. There are quite a few treatment options available now versus when I was your age so something is bound to help. I can relate to the shakes. On bad days, I get them myself. I have no idea the cause and come to think of it, I have never mentioned them to my doctors. I always attributed them to being anxious and more of a distraction from what was going on (or not going on) on the toilet. I would continue to mention them to your doctor. ER isn't the best place for gut help. They don't necessarily have the training that a gastro doctor does. For your anxiety, have you considered treating that with meds? The same meds that treat your anxiety might help your constipation. These drugs are called SSRI's. In the right dosage they could help anxiety and depression and also cramping and relieve constipation. If you don't want to go that route, then there are medications that are specifically for IBS-C. Has your doctor ever recommended those? You will hopefully get your anxiety under control by relieving your cramping and constipation. J*
  27. Jeffrey Roberts

    Gut Feeling - WHYY

    Gut Feeling Air Date: September 13, 2019 You know when you get butterflies in your stomach? Or your gut clenches with fear? Or the way a gory movie can fill you with nausea? Those feelings exist because of a special connection between our heads and our tummies called the gut-brain axis. On this episode, we explore how that connection works, the strange effects it can have on our stomachs (and our minds), and why scientists are creating “guts on chips” that mimic our digestive systems. https://whyy.org/episodes/gut-feeling/ © WHYY 2019
  28. Hi, I'm new to this group and mainly wanting to know if my symptoms are related to by anyone else. I surely feel quite alone in them. I am 18, and I was told by a gastro that I "probably" have IBS-C. I started taking Miralax regularly and that relieved some of the symptoms, but always caused a bit of diarrhea, so I would have to back off for a little bit and then start again. Things started to get bad when I stopped taking Miralax for an extended period of time and also got off of Prozac for depression, honestly because I thought that I "probably" was fine and wanted so badly to just have normal bowels. I woke up one night with intense abdominal pain, nausea, sweating, increased heartbeat, and shaking uncontrollably. I felt like I was dying. After going to the ER several weeks later, I saw in an x-ray that only a very small sliver of my whole torso was not full of stool. The ER also told me that the shakes were "poop shivers" and that I didn't have to worry. I had an intense "cleaning out" period, but the problems aren't gone. I have horrible cramping and nausea every single day and it's beginning to affect my functionality in school. Frankly, I am scared that I won't live a productive life. I also have anxiety and depression, and my anxiety is at an all time high. I still get the shakes, and they are violent and uncontrollable almost every time I have a bowel movement, before and after. They are physically exhausting and very troubling. Does anyone else have shakes? Why can't I find any information about IBS and shaking anywhere? Maybe this is not a normal symptom, in which case I would like to know that. Thanks for listening.
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