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  2. I have been struggling with IBS/D for at least 30 years. My trigger is usually (too much) coffee but lately have had serious flareups during shopping (of all things). Just casual, browsing shopping! I take a prescription hyoscyamine sulfate as needed, which usually take 2-3 doses before everything is calmed down. Years ago, it was tied more to my menstrual cycle but surgery (hysterectomy) helped. I am wondering if anyone has ever experienced shopping as a trigger? Thanks!
  3. Today
  4. Jeffrey Roberts

    Swelling, burning and weight gain

    Long term on zopac? It is a drug that has its own issues and really should only be used short term. A family doctor is able to diagnose IBS based on your history and symptoms. I worry that you've been provided with a highly addictive anti-anxiety medication that likely will have no effect on your symptoms. If it's possible, I would seek the help of a different physician.
  5. The FODMAP diet is everywhere, but researchers warn it's not for weight loss The Conversation AU The FODMAP diet is used to help manage irritable bowel syndrome (IBS), but it’s becoming more popular. Now bloggers and so-called health gurus have jumped on board, claiming it can treat everything from acne to weight loss. While it would be great if the diet did help to manage these hard-to-treat conditions, these claims are closer to science fiction than science. View the full article
  6. Fructose intolerance: Symptoms and management Medical News Today Fructose is a sugar that occurs naturally in fruits, vegetables, and honey. When a person is unable to digest or absorb fructose, they may have fructose intolerance. When a person has an intolerance to fructose, they may experience bloating, abdominal pain, and diarrhea. People with a more severe form of fructose intolerance called hereditary fructose intolerance will develop symptoms in infancy. Without treatment, they may develop life threatening complications, such as liver and kidney failure. View the full article
  7. Sheryl

    Swelling, burning and weight gain

    My doctor diagnosed me with ibs and I watch what I eat but that too isn't helping. My doctor gave me zopac to calm down my system
  8. Jeffrey Roberts

    Swelling, burning and weight gain

    Welcome Sheryl, Unfortunately, there isn't a really good answer to give for these symptoms. The only clue is your tummy is swelling. Have you considered a low FODMAP diet as this may help with the bloating and in turn, pain.
  9. This is such a useful video to expain the brain-gut interaction especially related to on-going pain. #IBS #IBD Thank you! https://twitter.com/johannahruddy/status/1231275150626246658 (Feed generated with FetchRSS) View the full article
  10. RT @TuesdayNightIBS: #TuesdayNightIBS is just around the corner. We hope you can join us on Tuesday at 7pm EST for this week's discussion related to the question "Do IBS Patients accurately report GI symptoms?" https://t.co/2NErH8J0Bv (Feed generated with FetchRSS) View the full article
  11. Yesterday
  12. Please can someone help with a relief. My tummy swells, and I have gained so much weight, I suffer with burning urine after eating certain foods and I am in so much pain. I can't take it. Here in Sa gastroenterologist doctors are super expensive and what is an alternative. Really dying here please help
  13. Thank you! I'll hold onto that for my next presentation.
  14. 12 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: irritable bowel syndrome These pubmed results were generated on 2020/02/23 PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. View the full article
  15. 12 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: irritable bowel syndrome These pubmed results were generated on 2020/02/23 PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. View the full article
  16. Ken Stovall

    IBS and Stomach Spasms

    Now that I’ve been back on Dicyclomine it’s been working great.... my Dr told be to take 20mg every 6 hours and it has stopped my stomach spasms 99.9 % and after 2 day of back to back almost 100%...... to me it’s been a miracle drug! I have found that when things calm down then I only take it when things flare up. I have also been eating activia yogurt in the morning with a light breakfast and one before I go to bed with a little water and that has been giving me the probiotics that I thought for years that I did not need but now I’m a believer on that as well. I also eat a lot of chicken, rice, certain beans and white bread, tuna in water for lunch with light chips, hot tea instead of coffee and no more artificial sugar.... only real sugar. it’s been a life change for me but feeling good again is worth every bit of it! Ken
  17. Mary Lou Lindsay

    IBS and Stomach Spasms

    After a lifetime of IBS, I am going to start taking the drug mentioned above. I am 78 years old and extremely physically active. My IBS has grown worse and worse and I do not want to be housebound by this monster lurking behind everything I eat. I keep trying to find the perfect diet but one day a food is fine and two two later, it is not. Willing to try anything.
  18. In case you’re not following yet, please follow the @TuesdayNightIBS page created by myself and @IBSpatient for clinicians & patients to engage around the complexities of #IBS which effects millions of patients! Patient cases, science/data, new studies & more! 7pmET each Tuesday! (Feed generated with FetchRSS) View the full article
  19. Last week
  20. Learned something totally new today from @BiancaWChangMD: The Latin roots of the words nausea and vomiting!👇 (Feed generated with FetchRSS) View the full article
  21. Bioinformatics analysis of gene and microRNA targets for fibromyalgia. Clin Exp Rheumatol. 2020 Feb 14; Authors: Qiu Y, Zhang TJ, Meng LB, Cheng XT, Hua Z Abstract OBJECTIVES: Fibromyalgia (FM) is the most common chronic pain disease in middle-aged women. Patients may also complain of migraine, irritable bowel syndrome and depression, which seriously affect their work and life, causing huge economic losses to society. However, the pathogenesis of FM is still controversial and the effect of the current treatment is far from satisfactory. METHODS: Differentially expressed genes (DEGs) and miRNAs (DEMs) were found between FM and normal blood samples. The pathway and process enrichment analysis of the genes were performed. Protein-protein interaction network were constructed. Hub genes were found and analysed in The Comparative Toxicogenomics Database. RESULTS: A total of 102 genes were up-regulated and 46 down-regulated, 206 miRNAs down-regulated, and 15 up-regulated in FM. CD38, GATM, HDC, FOS were found as canditate genes. These genes were significantly associated with musculoskeletal disease, mental disorder, immune system disease. There was partial overlap between metformin therapy-related genes and FM-related genes. CONCLUSIONS: We found DEGs and DEMs in FM patients through bioinformatics analysis, which may be involved in the occurrence and development of FM and serve as potential targets for diagnosis and treatment. PMID: 32083545 [PubMed - as supplied by publisher] View the full article
  22. Prostaglandin E2, Produced by Mast Cells in Colon Tissues from Patients with Irritable Bowel Syndrome, Contributes to Visceral Hypersensitivity in Mice. Gastroenterology. 2020 Feb 18;: Authors: Grabauskas G, Wu X, Gao J, Li JY, Turgeon DK, Owyang C Abstract BACKGROUND & AIMS: Visceral hypersensitivity is common in patients with irritable bowel syndrome (IBS). We investigated whether inflammatory molecules, such as histamine and proteases, activate prostaglandin-endoperoxide synthase 2 (PTGS2, also called COX2) to increase the synthesis of prostaglandin E2 (PGE2) by mast cells, which activates the receptor PTGER2 (also called EP2) in the dorsal root ganglia to promote visceral hypersensitivity. METHODS: We used an ELISA to measure levels of spontaneous release of molecules from mast cells in colonic mucosa from patients with IBS with diarrhea (IBS-D; 18 women and 5 men; ages 28 to 60 y), healthy individuals (controls, n=24), mice, and rats. We measured visceromotor responses to colorectal distension in rodents following intracolonic administration of colon biopsy supernatants, histamine, PGE2, a small interfering RNA against EP2, or an agonist of F2R like trypsin receptor 1 (F2RL1, also called PAR2). We investigated the role of COX2, produced by mast cells, in mediation of visceral hypersensitivity using mice with the Y385F substitution in Ptgs2 (Ptgs2Y385F mice), mast cell-deficient (W/WV) mice, and W/WV mice given injections of mast cells derived from wild-type or Ptgs2Y385F mice. RESULTS: Colon biopsies from patients with IBS-D had increased levels of PGE2, based on ELISA, and COX2 mRNA and protein, compared with control biopsies. Immunohistochemistry showed that most of the COX2 was in mast cells. Intracolonic infusions of rats with IBS-D biopsy supernatants generated a 3-4-fold increase in visceromotor responses to colorectal distension; this was associated with significant increases in PGE2, histamine, and tryptase in the colonic mucosa. These increases were prevented by a mast cell stabilizer, COX2 inhibitor, or knockdown of EP2. Intracolonic administration of supernatants from biopsies of patients with IBS-D failed to induce visceral hypersensitivity or increase the level of PGE2 in W/WV and Ptgs2Y385Fmice. Reconstitution of mast cells in W/WV mice restored the VH response. CONCLUSIONS: Abnormal synthesis of PGE2 by colonic mast cells appears to induce visceral hypersensitivity in patients with IBS-D. PMID: 32084424 [PubMed - as supplied by publisher] View the full article
  23. Environmental enrichment prevents chronic stress-induced brain-gut axis dysfunction through a GR-mediated mechanism in the central nucleus of the amygdala. Neurogastroenterol Motil. 2020 Feb 21;:e13826 Authors: Orock A, Louwies T, Yuan T, Greenwood-Van Meerveld B Abstract BACKGROUND: Cognitive behavioral therapy (CBT) improves quality of life of patients with irritable bowel syndrome (IBS), a disorder characterized by chronic visceral pain and abnormal bowel habits. Whether CBT can actually improve visceral pain in IBS patients is still unknown. The aim of this study is to evaluate whether environment enrichment (EE), the animal analog of CBT, can prevent stress-induced viscero-somatic hypersensitivity through changes in glucocorticoid receptor (GR) signaling within the central nucleus of the amygdala (CeA). METHODS: Rats were housed in either standard housing (SH) or EE for 7 days before and during daily water avoidance stress (WAS) exposure (1-h/d for 7 days). In the first cohort, visceral and somatic sensitivity were assessed via visceromotor response to colorectal distention and von Frey Anesthesiometer 24 hous and 21 days after WAS. In another cohort, the CeA was isolated for GR mRNA quantification. KEY RESULTS: Environment enrichment for 7 days before and during the 7 days of WAS persistently attenuated visceral and somatic hypersensitivity when compared to rats placed in SH. Environment enrichment exposure also prevented the WAS-induced decrease in GR expression in the CeA. CONCLUSION & INFERENCES: Pre-exposure to short-term EE prevents the stress-induced downregulation of GR, and inhibits visceral and somatic hypersensitivity induced by chronic stress. These results suggest that a positive environment can ameliorate stress-induced pathology and provide a non-pharmacological therapeutic option for disorders such as IBS. PMID: 32084303 [PubMed - as supplied by publisher] View the full article
  24. Related ArticlesComplementary and Alternative Medicine for Functional Gastrointestinal Disorders. Am J Gastroenterol. 2020 Feb 20;: Authors: Deutsch JK, Levitt J, Hass DJ Abstract The relevance of functional gastrointestinal (GI) disorders and their impact on quality of life for many patients has become an increasingly important topic in gastroenterology. A gastroenterologist can expect to see 40% of patients for motility and functional GI disorders, thus highlighting the necessity for physicians to have a strong foundation of knowledge in treatment strategies for these patients with complex disorders. A significant number of patients who suffer with functional GI disorders turn to complementary and alternative therapies to maintain control over their symptoms and often are happy with therapeutic results. This narrative presents information and treatment algorithms for the gastroenterologist to better understand and use some of the most common complementary and alternative therapies for patients with functional dyspepsia, nausea and vomiting, and irritable bowel syndrome. PMID: 32079860 [PubMed - as supplied by publisher] View the full article
  25. Health Reporter

    Pubmed-Safety of Eluxadoline Use.

    Related ArticlesSafety of Eluxadoline Use. Am J Gastroenterol. 2019 07;114(7):1176-1177 Authors: Lai SW PMID: 30920418 [PubMed - indexed for MEDLINE] View the full article
  26. We would like to welcome Fenuflakes™ from Natrusolate to our #MonashFODMAPCertified program. Fenuflakes™ are a #lowFODMAP food ingredients made from defatted fenugreek seeds & are an excellent source of BCAA and dietary fibre! Find out more here: https://bit.ly/32czUQ9 (Feed generated with FetchRSS) View the full article
  27. Uncomfortable and confused, as if the last worry on my mind should be, "Is my body going to do it's job today?"
  28. Great poll! We'll ask patients how this question might be phrased so that they and their health care provider feel comfortable about #sex and #IBS. https://twitter.com/tuesdaynightibs/status/1230952088240295936 (Feed generated with FetchRSS) View the full article
  29. RT @StanfordMed: "There are more bacteria on your hands than anywhere else," says Stanford Clinical Associate Professor Terry Platchek. That's why it's so important to wash your hands properly. http://bit.ly/2SJiPu0 (Feed generated with FetchRSS) View the full article
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