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  2. Giant spider provides promise of pain relief for irritable bowel syndrome UQ News Molecules from the venom of one of the world’s largest spiders could help University of Queensland-led researchers tailor pain blockers for people with irritable bowel syndrome (IBS). Researchers screened 28 spiders, with the venom of the Venezuelan Pinkfoot Goliath tarantula – which has a leg-span of up to 30 centimetres – showing the most promise. View the full article
  3. Endometriosis and irritable bowel syndrome: a systematic review and meta-analysis. Arch Gynecol Obstet. 2020 Sep 19;: Authors: Chiaffarino F, Cipriani S, Ricci E, Mauri PA, Esposito G, Barretta M, Vercellini P, Parazzini F Abstract PURPOSE: Irritable bowel disease and endometriosis are two common diseases characterized by chronic inflammation state and recurrent abdominal pain. As a consequence of sharing of symptoms and chronic inflammation, endometriosis and IBS may coexist and be misdiagnosed and this leads to delays in diagnosis, mismanagement, and unnecessary testing. In recent years, some studies have found higher risk of IBS in women with endometriosis, compared to women without endometriosis. To provide a general overview, we performed a systematic review and a meta-analysis on published data on this issue. METHODS: By a systematic literature search selection process, 11 studies were identified for the current study: 2 prospective and 2 retrospective cohort studies, 4 case-control studies, 1 cross-sectional study and 2 clinical series. RESULTS: When we meta-analysed data about the prevalence of IBS in women with endometriosis, the overall OR (95%CI), compared to women without endometriosis was 3.26 (1.97-5.39) with no statistically significant heterogeneity. All three studies considering the incidence of IBS in women with a previous diagnosis of endometriosis showed about twofold greater risk among women with endometriosis than women without. Likewise, in the random effects model of the meta-analysis, the overall OR of history of IBS in women with endometriosis was 3.10 (95% CI 2.06-4.67), with no heterogeneity between three studies considered. CONCLUSION: This meta-analysis provides epidemiological evidence of a link between endometriosis and IBS, highlighting two or more times higher risk of IBS in women with endometriosis compared to women without the condition. PMID: 32949284 [PubMed - as supplied by publisher] View the full article
  4. Can unrecognized fecal loading without infrequent bowel movements be a cause of symptoms in a subset of patients with functional bowel disorders? Indian J Gastroenterol. 2020 Sep 19;: Authors: Kang JY, Kang JH, Munneke G, Hayat J, Gwee KA Abstract Infrequent bowel movements are a common feature of constipation, but fecal loading as a cause of symptoms in patients with regular bowel movements has not previously been evaluated. The aim of this preliminary study was to assess prospectively if fecal loading may be a cause of bowel symptoms in patients with regular bowel movements. Consecutive patients attending a gastroenterology clinic for functional bowel symptoms (FBD) not including infrequent bowel movements and who did not fulfil the criteria for constipation-predominant irritable bowel syndrome or functional constipation underwent plain abdominal radiography. Those with fecal loading received dietary advice and laxative treatment. The reproducibility of determination of fecal loading using the Leech score was assessed 'blindly' by a consultant radiologist. Twenty-six of 74 patients with FBD but not infrequent bowel movements had fecal loading demonstrated on abdominal radiology. Their Leech scores were significantly higher than those of control patients matched for age, sex and hospital (median 6 vs. 4, IQR 5-7 vs. 3.5-5, p < 0.001). Three out of 20 patients (15%) who returned for review after dietary advice and laxatives were asymptomatic and 17/20 (85%) had improved. Fecal loading may therefore cause bowel symptoms in patients who move their bowels regularly and dietary and laxative treatment may then improve these symptoms. This approach may prove cost-effective as an empirical interim measure especially where healthcare resources are limited and where sophisticated imaging is not readily available. PMID: 32949354 [PubMed - as supplied by publisher] View the full article
  5. 🌵🌵Our pilot RCT of nopal cactus fibre shows positive outcomes in #IrritableBowelSyndrome #IBS🌵🌵 Just completed a large clinical trial with @chemaremes @TheGutHealthDoc @GutDocSam... about to start analysis... watch this space! Pilot RCT👉🏽@NGMJournal https://onlinelibrary.wiley.com/doi/10.1111/nmo.13986 (Feed generated with FetchRSS) View the full article
  6. A low frequency of post infection-IBS in patients attended in a tertiary referral center in México. Rev Esp Enferm Dig. 2019 Dec;111(12):914-920 Authors: Rivera-Lechuga D, Santana-Vargas D, Escamilla-Diego E, Charúa-Guindic L, Schmulson M Abstract BACKGROUND: PI-IBS prevalence is around 10.1%-14.5% ≥ 12 months after infectious gastroenteritis in North America, Europe and Asia. However, there are no studies from Latin America. Two previous studies in Mexico suggest a low incidence of 5%. AIMS: to determine the prevalence of PI-IBS in patients attended in a tertiary-care center, as well as IBS subtypes, severity, other digestive symptoms and red flags vs nPI-IBS. METHODS: seventy IBS patients screened for immunological research completed the Rome III, Spiller's for PI-IBS and IBS-SSS questionnaires. PI-IBS prevalence was determined according to three criteria sets. C1: ≥ 2 episodes of sudden onset, onset while traveling, initial illness with any of the following symptoms, fever, vomiting, bloody diarrhea and a positive stool culture. C2: sudden onset and > 2 episodes of fever, diarrhea, vomiting and bloody diarrhea. C3: sudden onset after an infectious episode such as a positive culture or onset with ≥ 2 episodes of fever, vomiting, diarrhea, rectal bleeding and foreign travel. Items were dichotomized as present or absent and compared using the Fisher's exact and Mann-Whitney U tests. RESULTS: PI-IBS prevalence was as follows. C1: 5.7%, C2: 0 and C3: 1.4%. There were no IBS-C or IBS-M cases. In the C1 group, one case was mild and three were moderate IBS, which was similar to the non PI-IBS group. One case in the C3 group had mild IBS. There were no differences in the frequency of esophageal, gastroduodenal, anorectal, bloating/distension and red flags between PI-IBS and non PI-IBS groups (analyzed only for C3). CONCLUSIONS: in Mexico, there is a very low prevalence of PI-IBS in patients from a tertiary-referral center. However, it varies according to the surrogate-criteria used. The later needs to be taken into account when performing PI-IBS studies. PMID: 31718206 [PubMed - indexed for MEDLINE] View the full article
  7. How fructophilic lactic acid bacteria may reduce the FODMAPs content in wheat-derived baked goods: a proof of concept. Microb Cell Fact. 2020 Sep 17;19(1):182 Authors: Acín Albiac M, Di Cagno R, Filannino P, Cantatore V, Gobbetti M Abstract BACKGROUND: FODMAPs (Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) intake is associated with the onset of irritable bowel syndrome symptoms. FODMAPs in wheat-derived baked goods may be reduced via bioprocessing by endogenous enzymes and/or microbial fermentation. Because of the inherent enzyme activities, bread made by baker's yeast and sourdough may result in decreased levels of FODMAPs, whose values are, however, not enough low for people sensitive to FODMAPs. RESULTS: Our study investigated the complementary capability of targeted commercial enzymes and metabolically strictly fructophilic lactic acid bacteria (FLAB) to hydrolyze fructans and deplete fructose during wheat dough fermentation. FLAB strains displayed higher fructose consumption rate compared to conventional sourdough lactic acid bacteria. Fructose metabolism by FLAB was faster than glucose. The catabolism of mannitol with the goal of its reuse by FLAB was also investigated. Under sourdough conditions, higher fructans breakdown occurred in FLAB inoculated doughs compared to conventional sourdough bacteria. Preliminary trials allowed selecting Apilactobacillus kunkeei B23I and Fructobacillus fructosus MBIII5 as starter candidates, which were successfully applied in synergy with commercial invertase for low FODMAPs baking. CONCLUSIONS: Results of this study clearly demonstrated the potential of selected strictly FLAB to strongly reduce FODMAPs in wheat dough, especially under liquid-dough and high oxygenation conditions. PMID: 32943064 [PubMed - in process] View the full article
  8. Changes in fecal short-chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome. Neurogastroenterol Motil. 2020 Sep 17;:e13983 Authors: El-Salhy M, Valeur J, Hausken T, Gunnar Hatlebakk J Abstract BACKGROUND: Short-chain fatty acids (SCFAs) may play a role in the pathophysiology of irritable bowel syndrome (IBS). This study analyzed fecal SCFAs after performing fecal microbiota transplantation (FMT) in the IBS patients who were included in our previous study of the efficacy of FMT. METHODS: This study included 142 of the 164 IBS patients who participated in our previous study. They were belonging to three groups: placebo (own feces), 30-g (superdonor feces), and 60-g (superdonor feces) FMT. The patients completed the IBS Severity Scoring System (IBS-SSS) Birmingham IBS Symptom, Fatigue Assessment Scale (FAS), the IBS Quality of Life (IBS-QoL) and Short-Form Nepean Dyspepsia Index (SF-NDI) questionnaires and delivered fecal samples at the baseline and 1 month after FMT. The SCFA levels were determined by vacuum distillation followed by gas chromatography. KEY RESULTS: The fecal butyric acid level was significantly increased after FMT in both the 30-g and 60-g groups (both P ≤ 0.001). In the 60-g group, the levels of total SCFAs and isobutyric, isovaleric, and valeric acids increased after FMT. Butyric acid levels in the responders in both the 30-g and 60-g FMT groups were significantly inversely correlated with IBS-SSS and FAS scores (P = 0.001, r = -0.3 and P = 0.0001. r=- 0.3, respectively). There were no differences in the SCFA levels in the placebo group after FMT. CONCLUSION AND INFERENCES: FMT increases the fecal SCFA levels in IBS patients. The increase in the butyric acid level is inversely correlated with symptoms in IBS patients following FMT, suggesting that SCFAs might play a role in the pathophysiology of IBS. www.clinicaltrials.gov (NCT03822299). PMID: 32945066 [PubMed - as supplied by publisher] View the full article
  9. Density of Musashi‑1‑positive stem cells in the stomach of patients with irritable bowel syndrome. Mol Med Rep. 2020 Aug 04;: Authors: El-Salhy M, Hausken T, Hatlebakk JG Abstract Irritable bowel syndrome (IBS) affects ~12% of the global population. Although the etiology of IBS is not completely understood, several factors are known to serve a pivotal role in its pathophysiology, including genetic factors, diet, the intestinal microbiota, gastrointestinal endocrine cells and low‑grade inflammation. Musashi‑1 is expressed by stem cells and their early progeny, and is used as a stem cell marker. The low density of intestinal endocrine cells in patients with IBS is thought to be caused by decreased numbers of intestinal stem cells and their differentiation into enteroendocrine cells. The present study employed Musashi‑1 as a marker to detect stem cells in the stomach of 54 patients with IBS and 51 healthy subjects. The patients and controls underwent standard gastroscopy, and biopsy samples were taken from the corpus and antrum. Immunohistochemical staining of gastrin, somatostatin and Mushasi‑1 was carried out and semi‑quantified by computerized image analysis. The density (number of positive cells/mm2 epithelium) of gastrin‑positive cells in the controls and patients with IBS were 337.9±560 and 531.0±908 (median ± range; P<0.0001), respectively. For somatostatin‑positive cells, the density reached 364.4±526.0 in the healthy controls and 150.7±514.0 in patients with IBS (P<0.0001). The density of Musashi‑1‑positive cells was defined as the number of cells per gastric or pyloric gland neck. In the corpus, Musashi‑1‑positive cells density reached 3.0±7.0 in the corpus of the healthy controls and 3.8±7.7 in the patients with IBS. Moreover, the corresponding values in the antrum were 6.0±6.0 and 6.0±6.0, respectively. The Musashi‑1‑positive cell density did not differ significantly between the controls and patients with IBS in the corpus or antrum (P=0.4 and 0.3, respectively). These findings indicated that changes in the stomach endocrine cells observed in patients with IBS may not be explained by an abnormality in stem cells like those found in the small and large intestines of these patients. PMID: 32945509 [PubMed - as supplied by publisher] View the full article
  10. Last week
  11. Do you have our app yet? If not, download it today to have all of Rome's information in the palm of your hand! Google Play//bit.ly/2FFOuZA App Store: https://apple.co/3iHml2s (Feed generated with FetchRSS) View the full article
  12. Have you tried a totally gluten free diet? You may have gluten intolerance. My symptoms improved tremendously after I went gluten free. There are lots of websites to help you learn how to handle the diet. The only thing you must accept is there will be a penalty to pay when you mess up and eat some gluten. Also I had a long period where I had to go to the restroom immediately after eating. If I was eating in a restaurant, I had to scout out the location of the nearest restroom. Turns out I had "Giardia", a parasitic infection. I also suffer from anxiety as well and have had a few panic attacks. Not fun!
  13. Jeffrey Roberts

    New in the group!

    Hello Verduzco, IBS is chronic; however, there are several treatment options including medication. You really don't have to live with daily stomach pain and discomfort. Do you have diarrhea or constipation associated with the pain?
  14. Shana Tova to all those celebrating this evening. May 5781 be a sweet and healthy year!
  15. Tara Lipinski opens up about undergoing endometriosis surgery to break taboo of 'hush hush topic' Everett Post (NEW YORK) — Olympic gold-medal-winning figure skater Tara Lipinski is opening up about undergoing endometriosis surgery in hopes of breaking down barriers around the condition that affects millions of women. “The irony of my endometriosis diagnosis is that I knew almost nothing about a disorder that affects one in 10 women. That’s 176 million people,” Lipinski shared on Instagram. “I’d never heard another woman mention ‘endo’ or the complications and pain that accompany it. And that definitely shows the lack of information that’s out there and the comfort level that affected women have discussing their endometriosis.” “To me, it feels like a hush hush topic that women feel they just need to tough out,” the 38-year-old wrote. “No woman should live in pain or think ‘this is just something I have to deal with."” Endometriosis, a medical condition whereby the lining of the uterus grows outside of the uterus, may affect more than 11 percent of American women between the ages of 15 and 44, according to the U.S. Department of Health and Human Services Office on Women’s Health (OWH). View the full article
  16. Jeffrey Roberts

    New here

    I'm mindful of eating low FODMAP foods and I'm also lactose intolerant so no dairy products. Sushi (nothing raw) All meats (other than chicken) - burgers, kabobs, steak, chops All fish - grilled, bbq'ed Shrimp - chinese food, bbq'ed Pasta w/veg
  17. The characteristics of intestinal flora of IBS-D with different syndromes. Immun Inflamm Dis. 2020 Sep 17;: Authors: Chao G, Zhang S Abstract OBJECTIVE: To study the distribution of fecal microbiota in diarrhea-predominant irritable bowel syndrome (IBS-D) patients of spleen-kidney-yang deficiency and liver depression and spleen deficiency, to make an objective foundation for dialectics of different type of IBS-D. And to provide the clinical doctors an experimental basis for medication by regulating dysbacteriosis. METHODS: We collected feces from the control group, spleen-kidney-yang deficiency IBS-D group, and liver-depression and spleen-deficiency IBS-D group. After the extraction of fecal DNA, global DNA was isolated from every sample, and 16S ribosomal RNA was sequenced, and then we analyzed the results for bacteria such as Alpha diversity, community composition, LEfSe, and partial least squares discriminant analysis. RESULTS: We compared the changes among the fecal bacteria in the intestine of the IBS-D patients and healthy controls and found the specificity of spleen-kidney-yang deficiency syndrome and liver-depression and spleen-deficiency syndrome. The control group has the highest flora diversity (control group > liver-depression and spleen-deficiency > spleen-kidney-yang deficiency group). The control group, spleen-kidney-yang deficiency group, and liver-depression and spleen-deficiency group are different in phylum (Actinobacteria, Fusobacteria), class (Actinobacteria, Fusobacteria), order (Enterobacteriales, Bifidobacteriales, Fusobacteriales), and family (Bifidobacteriaceae, Ruminococcaceae, Enterobacteriaceae, Acidaminococcaceae, Veillonellaceae, Fusobacteriaceae). Bifidobacteriaceae and Ruminococcaceae in the control group, Enterobacteriales, Fusobacteriales, Acidaminococcaceae, and Phascolarctobacterium in the spleen-kidney-yang deficiency group, and streptococcus are the specific bacteria in the liver-depression and spleen-deficiency group. Intestinal flora disturbance is closely related to IBS-D. CONCLUSIONS: There is a correlation between traditional Chinese medicine syndrome type and intestinal flora. The control group, the spleen-kidney-yang deficiency group, and the liver-depression and spleen-deficiency group have specific bacteria. PMID: 32940426 [PubMed - as supplied by publisher] View the full article
  18. Hello everyone , I been diagnosed with IBS little over a year now , they told me is chronic and no medicine for it , but the stomach pain and discomfort is every day !! Is anyone out there having the same ? Is just me ? Sometimes can’t sleep thinking what if something else ? Is so stressful . Please help an share if u having the same daily problems as me .
  19. Violetdazey

    New to group and need 2nd opinion

    @Megan Leger your post is so relatable to me. I have post infectious IBS from getting e Coli. I too was in and out of the ER. Had an endoscopy, colonoscopy, gastric empty study, CT scan, blood tests, stool samples. Soooo many doctors appointments. It is soul crushing when you go to the ER with excruciating pain that you describe and they can't find anything wrong and can't fix you. I feel your pain. I ended up going to the Mayo Clinic and the GI doctor suggested IBgard, a low FODMAPs diet, stay hydrated, and drink peppermint or ginger tea. It completely turned me around and got me back to work (after having been out sick for over 2 months). Recently I have experienced a flair up that sent me spiraling into sadness, but it has subsided for the most part. I highly recommend IBgard and FDgard, but IBgard is the true knight in shining armor lol. The low FODMAPs diet helps immensely as well. By only eating foods that are low in FODMAPs (which are a type of carbohydrate found in certain foods of every food group that feed the bad bacteria in your gut. They also dehydrate you by pulling water from your body that your body uses to help digest high FODMAP foods) I have been able to get my life back. A good tool is to keep a journal or stomach diary as I call mine. I track what I eat, what supplements I take (like probiotics, IBgard, etc), what my bowel movements are like, my weight, and how I am feeling physically as well as mentally. I hope any of this information from my experience can help you And bring you comfort.
  20. Violetdazey

    New and frustrated

    @Inglewood Jack I am so sorry you are going through these troubles. It is so frustrating and makes you feel hopeless to not find an answer or remedy. You mentioned that you have tried peppermint oil. Have you ever tried IBgard? Also have you ever heard of candida? Other than my GI doctor I see a naturopath doctor who treats me for candida build up. From my experience many western doctors don't know a lot about it or if they do, think it is not affecting you because you don't have thrush or some sort of infection related to yeast. It can have a big effect on the digestive system though, like contribute to colitis and IBS, it is over looked or dismissed a lot.
  21. Are You Gassy And Bloated? Anti Aging News Is your tummy making loud noises, maybe you are too full to move around, pants feel too tight, feels like a hardball in your midsection, whatever symptom you are experiencing being gassy and bloated is not a good feeling. While there is no denying that diet contributes to gut health, there are still many potential causes of uncomfortable gastrointestinal symptoms. Typically when experienced after eating it most likely due to byproducts that are created by bacteria in the GI Tract to help break down food because eating increases the water content in the gut and drawing in fluids can make one feel bloated. View the full article
  22. Violetdazey

    New here

    @Jeffrey Roberts If you are out at a restaurant what do you usually order to eat? @Esjie Thank you. I think it's just a flair up. Luckily today has been a better day! Thanks for the tips!
  23. Violetdazey

    Replace This with That

    Alrighty! @Esjie I need to get a digital copy to my computer and I will upload tomorrow if possible
  24. I would be very interested in the Mayo's diet plan. @Violetdazey Yes please do upload it if you can.
  25. Esjie

    New here

    Hello @Violetdazey I am so sorry you have been through this horrible experience, got better, only to feel sick again recently. It's possible the recent tummy upset was something different? And hopefully something that will pass naturally given a little time? I read here: https://www.bestfoodfacts.org/fruit-vinegar/ ....that washing fruits and veggies in a 3 part water to one part vinegar works to remove many pathogens. They also mention a product called "Tsunami" as a food sanitiser. I have never heard of that because I am in UK. But my local health food store does stock VeggieWash, so if you can get that, or something similar, that's an option. On that website they also say that washing fresh fruit and veggies thoroughly in plain cold running water removes 98% of anything potentially nasty anyway. That's what I usually do. I hadn't reckoned in the possibility (as Jeff said above) that having IBS could make us more susceptible to infections. I didn't know that before, but I am listening.
  26. Jeffrey Roberts

    New here

    Super scary, but you don't want to be so scared that you can't eat. I just don't know enough about a vegetable wash for it to be useful. I use several simple rules. Never eat chicken outside my home Never eat raw vegetables Always warm up my leftovers to the same temperature it was when it was first cooked Never eat any leftovers older than 3 days Never eat leftover shell fish
  27. Violetdazey

    New here

    Food borne and bacterial illnesses are so scary! I wish I could avoid them forever by not eating meat, but of course you can contract them from vegetables and other ways. Any cleaning tips like a vegetable wash or something like that?
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