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  1. Today
  2. The FODMAP diet is everywhere, but researchers warn it's not for weight loss The Conversation AU The FODMAP diet is used to help manage irritable bowel syndrome (IBS), but it’s becoming more popular. Now bloggers and so-called health gurus have jumped on board, claiming it can treat everything from acne to weight loss. While it would be great if the diet did help to manage these hard-to-treat conditions, these claims are closer to science fiction than science. View the full article
  3. Fructose intolerance: Symptoms and management Medical News Today Fructose is a sugar that occurs naturally in fruits, vegetables, and honey. When a person is unable to digest or absorb fructose, they may have fructose intolerance. When a person has an intolerance to fructose, they may experience bloating, abdominal pain, and diarrhea. People with a more severe form of fructose intolerance called hereditary fructose intolerance will develop symptoms in infancy. Without treatment, they may develop life threatening complications, such as liver and kidney failure. View the full article
  4. This is such a useful video to expain the brain-gut interaction especially related to on-going pain. #IBS #IBD Thank you! https://twitter.com/johannahruddy/status/1231275150626246658 (Feed generated with FetchRSS) View the full article
  5. RT @TuesdayNightIBS: #TuesdayNightIBS is just around the corner. We hope you can join us on Tuesday at 7pm EST for this week's discussion related to the question "Do IBS Patients accurately report GI symptoms?" https://t.co/2NErH8J0Bv (Feed generated with FetchRSS) View the full article
  6. Yesterday
  7. 12 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: irritable bowel syndrome These pubmed results were generated on 2020/02/23 PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. View the full article
  8. 12 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: irritable bowel syndrome These pubmed results were generated on 2020/02/23 PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. View the full article
  9. In case you’re not following yet, please follow the @TuesdayNightIBS page created by myself and @IBSpatient for clinicians & patients to engage around the complexities of #IBS which effects millions of patients! Patient cases, science/data, new studies & more! 7pmET each Tuesday! (Feed generated with FetchRSS) View the full article
  10. Last week
  11. Learned something totally new today from @BiancaWChangMD: The Latin roots of the words nausea and vomiting!👇 (Feed generated with FetchRSS) View the full article
  12. Health Reporter

    Pubmed-Safety of Eluxadoline Use.

    Related ArticlesSafety of Eluxadoline Use. Am J Gastroenterol. 2019 07;114(7):1176-1177 Authors: Lai SW PMID: 30920418 [PubMed - indexed for MEDLINE] View the full article
  13. Related ArticlesComplementary and Alternative Medicine for Functional Gastrointestinal Disorders. Am J Gastroenterol. 2020 Feb 20;: Authors: Deutsch JK, Levitt J, Hass DJ Abstract The relevance of functional gastrointestinal (GI) disorders and their impact on quality of life for many patients has become an increasingly important topic in gastroenterology. A gastroenterologist can expect to see 40% of patients for motility and functional GI disorders, thus highlighting the necessity for physicians to have a strong foundation of knowledge in treatment strategies for these patients with complex disorders. A significant number of patients who suffer with functional GI disorders turn to complementary and alternative therapies to maintain control over their symptoms and often are happy with therapeutic results. This narrative presents information and treatment algorithms for the gastroenterologist to better understand and use some of the most common complementary and alternative therapies for patients with functional dyspepsia, nausea and vomiting, and irritable bowel syndrome. PMID: 32079860 [PubMed - as supplied by publisher] View the full article
  14. Bioinformatics analysis of gene and microRNA targets for fibromyalgia. Clin Exp Rheumatol. 2020 Feb 14; Authors: Qiu Y, Zhang TJ, Meng LB, Cheng XT, Hua Z Abstract OBJECTIVES: Fibromyalgia (FM) is the most common chronic pain disease in middle-aged women. Patients may also complain of migraine, irritable bowel syndrome and depression, which seriously affect their work and life, causing huge economic losses to society. However, the pathogenesis of FM is still controversial and the effect of the current treatment is far from satisfactory. METHODS: Differentially expressed genes (DEGs) and miRNAs (DEMs) were found between FM and normal blood samples. The pathway and process enrichment analysis of the genes were performed. Protein-protein interaction network were constructed. Hub genes were found and analysed in The Comparative Toxicogenomics Database. RESULTS: A total of 102 genes were up-regulated and 46 down-regulated, 206 miRNAs down-regulated, and 15 up-regulated in FM. CD38, GATM, HDC, FOS were found as canditate genes. These genes were significantly associated with musculoskeletal disease, mental disorder, immune system disease. There was partial overlap between metformin therapy-related genes and FM-related genes. CONCLUSIONS: We found DEGs and DEMs in FM patients through bioinformatics analysis, which may be involved in the occurrence and development of FM and serve as potential targets for diagnosis and treatment. PMID: 32083545 [PubMed - as supplied by publisher] View the full article
  15. Environmental enrichment prevents chronic stress-induced brain-gut axis dysfunction through a GR-mediated mechanism in the central nucleus of the amygdala. Neurogastroenterol Motil. 2020 Feb 21;:e13826 Authors: Orock A, Louwies T, Yuan T, Greenwood-Van Meerveld B Abstract BACKGROUND: Cognitive behavioral therapy (CBT) improves quality of life of patients with irritable bowel syndrome (IBS), a disorder characterized by chronic visceral pain and abnormal bowel habits. Whether CBT can actually improve visceral pain in IBS patients is still unknown. The aim of this study is to evaluate whether environment enrichment (EE), the animal analog of CBT, can prevent stress-induced viscero-somatic hypersensitivity through changes in glucocorticoid receptor (GR) signaling within the central nucleus of the amygdala (CeA). METHODS: Rats were housed in either standard housing (SH) or EE for 7 days before and during daily water avoidance stress (WAS) exposure (1-h/d for 7 days). In the first cohort, visceral and somatic sensitivity were assessed via visceromotor response to colorectal distention and von Frey Anesthesiometer 24 hous and 21 days after WAS. In another cohort, the CeA was isolated for GR mRNA quantification. KEY RESULTS: Environment enrichment for 7 days before and during the 7 days of WAS persistently attenuated visceral and somatic hypersensitivity when compared to rats placed in SH. Environment enrichment exposure also prevented the WAS-induced decrease in GR expression in the CeA. CONCLUSION & INFERENCES: Pre-exposure to short-term EE prevents the stress-induced downregulation of GR, and inhibits visceral and somatic hypersensitivity induced by chronic stress. These results suggest that a positive environment can ameliorate stress-induced pathology and provide a non-pharmacological therapeutic option for disorders such as IBS. PMID: 32084303 [PubMed - as supplied by publisher] View the full article
  16. Prostaglandin E2, Produced by Mast Cells in Colon Tissues from Patients with Irritable Bowel Syndrome, Contributes to Visceral Hypersensitivity in Mice. Gastroenterology. 2020 Feb 18;: Authors: Grabauskas G, Wu X, Gao J, Li JY, Turgeon DK, Owyang C Abstract BACKGROUND & AIMS: Visceral hypersensitivity is common in patients with irritable bowel syndrome (IBS). We investigated whether inflammatory molecules, such as histamine and proteases, activate prostaglandin-endoperoxide synthase 2 (PTGS2, also called COX2) to increase the synthesis of prostaglandin E2 (PGE2) by mast cells, which activates the receptor PTGER2 (also called EP2) in the dorsal root ganglia to promote visceral hypersensitivity. METHODS: We used an ELISA to measure levels of spontaneous release of molecules from mast cells in colonic mucosa from patients with IBS with diarrhea (IBS-D; 18 women and 5 men; ages 28 to 60 y), healthy individuals (controls, n=24), mice, and rats. We measured visceromotor responses to colorectal distension in rodents following intracolonic administration of colon biopsy supernatants, histamine, PGE2, a small interfering RNA against EP2, or an agonist of F2R like trypsin receptor 1 (F2RL1, also called PAR2). We investigated the role of COX2, produced by mast cells, in mediation of visceral hypersensitivity using mice with the Y385F substitution in Ptgs2 (Ptgs2Y385F mice), mast cell-deficient (W/WV) mice, and W/WV mice given injections of mast cells derived from wild-type or Ptgs2Y385F mice. RESULTS: Colon biopsies from patients with IBS-D had increased levels of PGE2, based on ELISA, and COX2 mRNA and protein, compared with control biopsies. Immunohistochemistry showed that most of the COX2 was in mast cells. Intracolonic infusions of rats with IBS-D biopsy supernatants generated a 3-4-fold increase in visceromotor responses to colorectal distension; this was associated with significant increases in PGE2, histamine, and tryptase in the colonic mucosa. These increases were prevented by a mast cell stabilizer, COX2 inhibitor, or knockdown of EP2. Intracolonic administration of supernatants from biopsies of patients with IBS-D failed to induce visceral hypersensitivity or increase the level of PGE2 in W/WV and Ptgs2Y385Fmice. Reconstitution of mast cells in W/WV mice restored the VH response. CONCLUSIONS: Abnormal synthesis of PGE2 by colonic mast cells appears to induce visceral hypersensitivity in patients with IBS-D. PMID: 32084424 [PubMed - as supplied by publisher] View the full article
  17. We would like to welcome Fenuflakes™ from Natrusolate to our #MonashFODMAPCertified program. Fenuflakes™ are a #lowFODMAP food ingredients made from defatted fenugreek seeds & are an excellent source of BCAA and dietary fibre! Find out more here: https://bit.ly/32czUQ9 (Feed generated with FetchRSS) View the full article
  18. Great poll! We'll ask patients how this question might be phrased so that they and their health care provider feel comfortable about #sex and #IBS. https://twitter.com/tuesdaynightibs/status/1230952088240295936 (Feed generated with FetchRSS) View the full article
  19. RT @StanfordMed: "There are more bacteria on your hands than anywhere else," says Stanford Clinical Associate Professor Terry Platchek. That's why it's so important to wash your hands properly. http://bit.ly/2SJiPu0 (Feed generated with FetchRSS) View the full article
  20. RT @MASTprogram: ICYMI - A comprehensive summary of the whole concept of the #microbiome and #IBS/#SIBO - by .@MarkPimentelMD and @AnthonyLemboMD This summarizes 20 years of work. https://rdcu.be/b1g54 (Feed generated with FetchRSS) View the full article
  21. Love the algorithm! 👇🏼 https://twitter.com/allergykidsdoc/status/1230860920429174786 (Feed generated with FetchRSS) View the full article
  22. After Elective Sigmoid Colectomy for Diverticulitis, Does Recurrence-Free Mean Symptom-Free? Am Surg. 2020 Jan 01;86(1):49-55 Authors: Choi KK, Krautsak K, Martinolich J, Canete JJ, Valerian BT, Chismark AD, Lee EC Abstract After elective sigmoidectomy for diverticulitis, patients may experience persistent abdominal symptoms. This study aimed to determine the incidence and characteristics of persistent symptoms (PSs) and their risk factors in patients who had no reported recurrence after elective sigmoidectomy. Patients who underwent elective sigmoidectomy for diverticulitis from 2002 to 2016 at a tertiary academic colorectal surgery practice were included. After retrospective review of medical records, patients were contacted with a questionnaire to inquire about recurrence of diverticulitis and persistent abdominal symptoms since resection. Outcomes examined were prevalence of and risk factors for PSs after elective sigmoidectomy. Of 662 included patients, 346 completed the questionnaire and had no recurrent diverticulitis. PSs were reported by 43.9 per cent of the patients. The mean follow-up was 87 months. Female gender and preoperative diagnosis of irritable bowel syndrome were independent risk factors for PSs (Relative Risk 1.65, P < 0.001 and Relative Risk 1.41, P = 0.014). Previous IV antibiotics treatment was associated with PSs (P = 0.034) but not with a significant risk factor. As the follow-up interval increased, prevalence of PSs decreased (P = 0.006). More than 40 per cent of patients experienced persistent abdominal symptoms after sigmoidectomy for diverticulitis. Female patients and those with irritable bowel syndrome were at significantly increased risk. PMID: 32077416 [PubMed - in process] View the full article
  23. Heat Shock Protein 27 Regulates the Inflammatory Response of Intestinal Epithelial Cells by the Nuclear Factor-κB Pathway. Dig Dis Sci. 2020 Feb 20;: Authors: Zhang Y, Wang X, Wang S, Yan Z, Li C, Zheng Y, Cui L Abstract BACKGROUND: The specific and accurate pathogenesis of diarrhea-type irritable bowel syndrome is still unclear. AIMS: We explored the mechanism of heat shock protein 27 (HSP27) in diarrhea-type irritable bowel syndrome to identify the key targets for the disease. METHODS: The human colonic epithelial cell lines Caco-2 and NCM460 were pretreated with KRIBB3 (a phosphorylation inhibitor of HSP27) and then stimulated with lipopolysaccharide for different times. The apoptosis ratios of Caco-2 and NCM460 cells were examined with Annexin V/PI assays. Cell growth was determined using the cell counting kit-8 assay, and the expression levels of IL-1β and IL-6 in the cell supernatant were analyzed by ELISA. In addition, the expression levels of HSP27 and the nuclear factor-κB (NF-κB) signaling pathway were examined by Western blot assay. RESULTS: Stimulation with lipopolysaccharide promoted the expression of HSP27 in colonic epithelial cells. HSP27 was phosphorylated at serine 78 and 82 after exposure to LPS. Apoptosis, growth inhibition, and inflammatory factor expression of lipopolysaccharide-induced colonic epithelial cells were greatly exacerbated by KRIBB3 treatment. In addition, KRIBB3 inhibited the phosphorylation of IκB-α and the activation of NF-κB. Gene silencing by small interfering RNA indicated that phosphorylation of HSP27 may regulate the NF-κB pathway. CONCLUSIONS: HSP27 plays an important role in the inflammatory response of intestinal human colonic epithelial cells. HSP27 may protect intestinal epithelial cells against damage by regulating the NF-κB pathway. PMID: 32078087 [PubMed - as supplied by publisher] View the full article
  24. RT @Jodinesmyth2: Please could anybody with irritable bowel disease complete my friends dissertation survey ❤️. It should only take 5-10 minutes https://ljmu.onlinesurveys.ac.uk/dietary-beliefs-and-eating-habits-of-those-with-ibd (Feed generated with FetchRSS) View the full article
  25. Irritable bowel syndrome in adults: diagnosis and management Book. 2008 02 23 Authors: Abstract Irritable bowel syndrome (IBS) is a chronic, relapsing and often life-long disorder. It is characterised by the presence of abdominal pain or discomfort, which may be associated with defaecation and/or accompanied by a change in bowel habit. Symptoms may include disordered defaecation (constipation or diarrhoea or both) and abdominal distension, usually referred to as bloating. Symptoms sometimes overlap with other gastrointestinal disorders such as non-ulcer dyspepsia or coeliac disease. People with IBS present to primary care with a wide range of symptoms, some of which they may be reluctant to disclose without sensitive questioning. People with IBS present with varying symptom profiles, most commonly ‘diarrhoea predominant’, ‘constipation predominant’ or alternating symptom profiles. IBS most often affects people between the ages of 20 and 30 years and is twice as common in women as in men. Prevalence in the general population is estimated to be between 10% and 20%. Recent trends indicate that there is also a significant prevalence of IBS in older people. IBS diagnosis should be a consideration when an older person presents with unexplained abdominal symptoms. Key aspects of this guideline include establishing a diagnosis; referral into secondary care only after identification of ‘red flags’ (symptoms and/or features that may be caused by another condition that needs investigation); providing lifestyle advice; drug and psychological interventions; and referral and follow-up. The guideline refers to NICE’s guideline on suspected cancer: recognition and referral in relation to appropriate referral to secondary care. The main aims of this guideline are to: provide positive diagnostic criteria for people presenting with symptoms suggestive of IBS; provide guidance on clinical and cost-effective management of IBS in primary care; determine clinical indications for referral to IBS services, taking into account cost effectiveness.RECOMMENDATIONS ABOUT MEDICINES: The guideline will assume that prescribers will use a medicine’s summary of product characteristics to inform decisions made with individual patients. This guideline recommends some medicines for indications for which they do not have a UK marketing authorisation at the date of publication, if there is good evidence to support that use. The prescriber should follow relevant professional guidance, taking full responsibility for the decision. The patient (or those with authority to give consent on their behalf) should provide informed consent, which should be documented. See the General Medical Council’s Good practice in prescribing and managing medicines and devices for further information. Where recommendations have been made for the use of medicines outside their licensed indications (‘off-label use’), these medicines are marked with a footnote in the recommendations. PMID: 32073807 View the full article
  26. Related ArticlesChemerin in immune response and gastrointestinal pathophysiology. Clin Chim Acta. 2020 Feb 15;504:146-153 Authors: Jacenik D, Fichna J Abstract Chemerin is a multifunctional protein involved among others in adipogenesis, angiogenesis and lipid as well as glucose metabolism. Chemerin is an essential factor in promotion of chemotaxis of numerous immune cell types and plays an important role in several pathophysiologic conditions. Chemerin receptors are present on monocytes/macrophages, T cells, natural killer and dendritic cells as well as neutrophils. However, the role of chemerin and chemerin receptors in immune response and gastrointestinal diseases is still poorly understood. Accumulating, clinical and experimental studies observed disturbation of chemerin and chemerin receptors in a number of disorders including Barrett's esophagus, esophageal cancer, gastric cancer, hepatic dysfunction, irritable bowel syndrome, inflammatory bowel disease and colorectal cancer. Moreover, chemerin and chemerin receptors have been shown to regulate proliferation, migration and invasion of gastrointestinal and immune cells as well as cancer-associated fibroblasts. In this review we present the current state of knowledge about the contribution of chemerin to immune response and gastrointestinal disorders. PMID: 32070869 [PubMed - as supplied by publisher] View the full article
  27. Google-Flushing IBS down the toilet - http://KHOU.com (video) http://dlvr.it/RQNsQD (Feed generated with FetchRSS) View the full article
  28. Flushing IBS down the toilet KHOU.com 15% of people are living with Irritable Bowel Syndrome, and almost a quarter of those people are undiagnosed. How to find out if you have it, and what do if you do! HOUSTON — Chanel Love is a Digestive health dietitian with a special interest in IBS & the Low FODMAP Diet. She provides an online nutrition program to help woman manage IBS so they can enjoy life symptom-free! View the full article
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