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  1. *This Friday* @US_FDA, ACG & like-minded organizations host: Pediatric #InflammatoryBowelDisease (#IBD) Workshop Who: Open to the public When: November 16 Where: FDA White Oak Campus, Silver Spring, MD There is no cost, but registration is required ➡️ (RSS generated with FetchRss) View the full article
  2. In case you missed the @CBSThisMorning segment on Saturday with Dr. @MarkPochapin, Dr. Seth Gross and @DrLaPook ⬇️ (RSS generated with FetchRss) View the full article
  3. These prepped carrots from Trader Joe's make roasting carrots just one step easier. Tasty, nutritious and low #FODMAP too. Drizzle with olive oil, season with a little salt+ roast them up. Delicious + EASY #Thanksgiving side dish. (RSS generated with FetchRss) View the full article
  4. Mesenteric vascular and nerve sparing surgery in laparoscopic segmental intestinal resection for deep infiltrating endometriosis. Eur J Obstet Gynecol Reprod Biol. 2018 Nov 01;231:214-219 Authors: Raffaelli R, Garzon S, Baggio S, Genna M, Pomini P, Laganà AS, Ghezzi F, Franchi M Abstract OBJECTIVE(S): To investigate Mesenteric vascular and nerve Sparing Surgery (MSS) as surgical laparoscopic technique to perform segmental intestinal resection for deep infiltrating endometriosis (DIE). STUDY DESIGN: Prospective cohort study between January 2013 and December 2016. Consecutive patients with suspected intestinal DIE underwent clinical and imaging evaluation to confirm intestinal involvement. Indications for radical surgery and surgical technique (intestinal resection versus shaving) were consistent with Abrão algorithm. Surgeons aimed to perform MSS in all the consecutive patients that required intestinal resection. MSS consists in mesenteric artery, branching arteries, and surrounding nerve fibers preservation by dissecting mesentery adherent to the intestinal wall. Data about history, preoperative and post-operative evaluation, surgery and complications were recorded. Symptoms were evaluated before and 30-60 days after surgery with numeric rating scale for pain. Constipation was evaluated with the Constipation Assessment Scale (CAS). Patients with diagnosis of irritable bowel syndrome, inflammatory bowel diseases, diverticulitis, and previous segmental intestinal resection were excluded. RESULTS: Sixty-two out of 75 (82.7%) consecutive women with intestinal endometriosis underwent laparoscopic segmental intestinal resection performed with MSS. Major complications that required repeated operation occurred in 4 cases (6.5%). Anastomotic leakage occurred in only 1 case (1.6%). Dysmenorrhea (p < .001; r = -0.86), dyspareunia (p < .001; r = -0.80), dyschezia (p < .001; r = -0.86) and dysuria (p < .001; r = -0.56) were significantly improved after surgery. After an average of 33.1 months from surgery, severe constipation was reported only by two patients (3.6%) (CAS: 13-16). The median time from surgery to intestinal function recovery (flatus or stool passage) was one day. Logistic regression analysis showed constipation related to the distance from anal verge and time since surgery. CONCLUSION(S): MSS in laparoscopic intestinal resection for DIE may be reproducible, safe and effective. MSS could be combined with pelvic nerve-sparing surgery as an effective approach to improve intestinal symptoms after radical surgery for DIE that requires segmental intestinal resection. PMID: 30415128 [PubMed - as supplied by publisher] View the full article
  5. Studying the #microbiome could be the next frontier in #coloncancer research. Rachel Sarnoff (@RSarnoff) joins CBS Chief Medical Correspondent @DrLaPook to discuss her research, including the study she presented at #ACG2018 ➡️ (RSS generated with FetchRss) View the full article
  7. Fecal Impaction: How to Come Unstuck from an Impacted Bowel Full coverage View the full article
  8. Physical Activity, #BMI, and Risk of Fecal Incontinence in the Nurses’ Health Study Read Staller, et al. in Clinical and Translational Gastroenterology ➡️ #CTGJournal (RSS generated with FetchRss) View the full article
  9. Related Articles Mood Disorders and Gluten: It's Not All in Your Mind! A Systematic Review with Meta-Analysis. Nutrients. 2018 Nov 08;10(11): Authors: Busby E, Bold J, Fellows L, Rostami K Abstract Gluten elimination may represent an effective treatment strategy for mood disorders in individuals with gluten-related disorders. However, the directionality of the relationship remains unclear. We performed a systematic review of prospective studies for effects of gluten on mood symptoms in patients with or without gluten-related disorders. Six electronic databases (CINAHL, PsycINFO, Medline, Web of Science, Scopus and Cochrane Library) were searched, from inception to 8 August 2018, for prospective studies published in English. Meta-analyses with random-effects were performed. Three randomised-controlled trials and 10 longitudinal studies comprising 1139 participants fit the inclusion criteria. A gluten-free diet (GFD) significantly improved pooled depressive symptom scores in GFD-treated patients (Standardised Mean Difference (SMD) -0.37, 95% confidence interval (CI) -0.55 to -0.20; p < 0.0001), with no difference in mean scores between patients and healthy controls after one year (SMD 0.01, 95% CI -0.18 to 0.20, p = 0.94). There was a tendency towards worsening symptoms for non-coeliac gluten sensitive patients during a blinded gluten challenge vs. placebo (SMD 0.21, 95% CI -0.58 to 0.15; p = 0.25). Our review supports the association between mood disorders and gluten intake in susceptible individuals. The effects of a GFD on mood in subjects without gluten-related disorders should be considered in future research. PMID: 30413036 [PubMed - in process] View the full article
  10. Related Articles Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity. J Pharmacol Exp Ther. 2018 Nov 09;: Authors: Russell J, Mohammadi E, Ligon CO, Johnson AC, Gershon MD, Rao M, Shen Y, Chan CC, Eidam HS, DeMartino MP, Cheung M, Oliff AI, Kumar S, Greenwood-Van Meerveld B Abstract Abdominal pain represents a significant complaint in patients with irritable bowel syndrome (IBS). While the etiology of IBS is incompletely understood, prior exposure to gastrointestinal (GI) inflammation or psychological stress is frequently associated with the development of symptoms. Inflammation or stress-induced expression of growth factors or cytokines may contribute to the pathophysiology of IBS. Here we aimed to investigate the therapeutic potential of inhibiting the receptor of glial cell line-derived neurotrophic factor (GDNF), rearranged during transfection (RET), in experimental models of inflammation and stress-induced visceral hypersensitivity resembling IBS sequelae. In RetCFP/+ mice, thoracic and lumbosacral dorsal root ganglia (DRG) were shown to express RET and co-localized with calcitonin gene-related peptide (CGRP). To understand the role of RET in visceral nociception, we employed GSK3179106 as a potent, selective, and gut-restricted RET kinase inhibitor. Colonic hyperalgesia quantified as exaggerated visceromotor response (VMR) to graded pressures (0-60 mmHg) of isobaric colorectal distention (CRD) was produced in multiple rat models induced by i) colonic irritation, ii) following acute colonic inflammation, iii) adulthood stress and iv) early life stress. In all the rat models, RET Inhibition with GSK3179106 attenuated the number of abdominal contractions induced by CRD. Our findings identify a role for RET in visceral nociception. Inhibition of RET kinase with a potent, selective, and gut-restricted small molecule may represent a novel therapeutic strategy for the treatment of IBS through the attenuation of post-inflammatory and stress-induced visceral hypersensitivity. PMID: 30413627 [PubMed - as supplied by publisher] View the full article
  11. DR. ISLAM: Don't ignore constipation Odessa American Full coverage View the full article
  12. RT @LizWeiss: Do you suffer from IBS? TUNE IN to the Liz's Healthy Table #PODCAST for my interview w/ gut health guru @KateScarlata_RD abou… (RSS generated with FetchRss) View the full article
  13. ⭐ RESEARCH UPDATE ⭐ Want to hear more about the new treatments and therapeutic targets for IBS and FBD? Read the new Nature article here: (RSS generated with FetchRss) View the full article
  14. If you are struggling with finding low FODMAP products in the US, Canada and UK, you may want to check out the Fody Food online shop. And if you place an order of at least $75, this week, you will also receive a FREE Fody... (RSS generated with FetchRss) View the full article
  15. Related Articles Refractory Irritable Bowel Syndrome and Functional Abdominal Pain Syndrome: Should Small Bowel Endoscopy Be Performed? Clin Endosc. 2018 Nov 09;: Authors: Yim SK, Kim SW PMID: 30408947 [PubMed - as supplied by publisher] View the full article