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Jeffrey Roberts posted a topic in Constipation predominant Irritable Bowel Syndrome (IBS-C) and Chronic Idiopathic Constipation (CIC)Zelnorm is a medication for constipation predominant IBS (IBS-C) that is returning to the market in the US after it was off the market for some years. It was re-approved early this year by the FDA and is now in pharmacies again. Zelnorm works differently than other medications for constipation. It increases the amount of serotonin in the gut in order to cause a bowel movement and relieve abdominal pain. More information about Zelnorm can be found here. Is there anyone who has been able to try Zelnorm (tegaserod) again for constipation predominant IBS (IBS-C)? I would be interested to know if it is working for you like it did when it was on the market before. or What was the perspective you had when you last used Zelnorm before it was removed from the market?