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Jeffrey Roberts posted a topic in General DiscussionL Chang: Wide prevalence of comorbid conditions in IBS. Quality of Life (QOL) suffers with the greater number of conditions L Chang: FGiDs (Functional Gastrointestinal Disorders) and IBS comorbidities especially significant for women L Chang: Role for central neuromodulators (antidepressants) for managing FGiDs and IBS L Chang: Tricyclic antidepressants are considered first line for pain modulation. SSRI's antidepressants not as effective for GI pain. SNRI's antidepressants effective for pain. Tetracyclic antidepressants for early satiety, nausea/vomiting, weight loss and sleep disturbance L Chang: New data with pregabalin (Lyrica) for greater than 3 FGiD pain attacks per month. Could be considered for pain L Chang: Co-morbid migraine: CGRP receptor antagonist for IBS-D/M might be an option