Real-World Data Highlight a New Approach to Chronic Constipation, With Darren Brenner, MD - HCPLive

Real-World Data Highlight a New Approach to Chronic Constipation, With Darren Brenner, MD  HCPLive

Brenner describes shortcomings of pharmacologic CIC options and reviews real-world data on the Vibrant System’s benefits in this context.

Chronic idiopathic constipation (CIC) remains one of the most challenging and heterogenous disorders encountered in GI practice. While clinicians today have a wide therapeutic armamentarium, including osmotic and stimulant laxatives, secretagogues, and prokinetic agents, each option carries limitations and side effects that impede adherence and patient satisfaction.

Against this backdrop, the vibrating capsule (Vibrant System) represents a novel, device-based therapeutic approach designed to enhance colonic motility without pharmacologic action. New real-world evidence published adds meaningful long-term data showing patients using the device for 3 and 6 months experienced improvements across multiple clinically relevant endpoints, including increased complete spontaneous bowel movements, reduced straining, and greater frequency of complete evacuation.

“Vibrant has a couple of different benefits. Number one, we know that it works,” Darren Brenner, MD, a professor of medicine and surgery in the division of gastroenterology at Northwestern University and serves as director of the Neurogastromotility and Interdisciplinary Bowel Dysfunction programs, told HCPLive. “We now have multiple data points showing that this can be effective, from the phase 3 trials that show that it could significantly improve one to two complete spontaneous bowel moments a week in patients to now our data showing that 3 to 6 months later, people are doing very well for multiple endpoints.”

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