Hello everyone, I'm new to this website, although not new to IBS. I was diagnosed with IBS-C many years ago at age 33. Zelnorm was a magical medication for me when it was available. Since then, I have tried Amitiza and Linzess, which I did not tolerate. I had high hopes for Motegrity, which is similar to Zelnorm in drug type and physiological action. Motegrity does work somewhat better for me if I take it first thing in the morning with 16 ounces of purified drinking water at room temperature, then have a high fiber breakfast about 1 to 1.5 hours later, followed by more drinking water. However, I still need to use over the counter (OTC) meds. Oh so very frustrating. I'm trying to take a break from Motegrity (about 2 to 5 consecutive days) if it seems like it's not working at all. Since our tap water is rated as very hard by the county water district (96 parts per billion, with high levels of calcium), I'm also trying to drink more purified water to see if this makes a difference. Thank you for this website and the opportunity to share and support each other. It is greatly appreciated.

Hello Robin,

Zelnorm was a miracle for so many and as you've pointed out Motegrity is a little bit different, though chemically very similar.

I wish there were definitive answers to managing IBS-C everyday. Drinking water and moving our bodies clearly is not the complete answer.