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Low Vitamin D levels impacts digestive health
Del Rio News Herald
Studies have found that low vitamin D levels can impact the severity of symptoms in persons suffering from Irritable Bowel Syndrome (IBS). In these studies, 82% of the individuals with low vitamin D had symptoms that were debilitating and affected ...

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Jeffrey Roberts

https://www.ncbi.nlm.nih.gov/pubmed/27154424

Neurogastroenterol Motil. 2016 Oct;28(10):1533-44. doi: 10.1111/nmo.12851. Epub 2016 May 7.

Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.

Abstract

BACKGROUND: 

Low-grade mucosal inflammation and immune activation are involved in the pathogenesis of irritable bowel syndrome (IBS). Furthermore, IBS symptoms are associated with a significantly higher prevalence of psychological distress, which in itself results into an impaired quality of life (QoL). Vitamin D could ameliorate the symptoms of patients suffering from IBS through its beneficial effects on psychological factors and inflammation.

METHODS: 

A total of 90 IBS patients participated in this double-blind, randomized, placebo-controlled study. Participants were randomly selected to receive either 50 000 IU vitamin D3 or a placebo fortnightly for a period of 6 months. Patients reported their IBS symptoms at the baseline and monthly during intervention periods. The IBS severity score system (IBSSS) and IBS-specific QoL questionnaires were used at the baseline and postintervention.

KEY RESULTS: 

Over the 6-month intervention period, a significantly greater improvement in IBS symptoms such as abdominal pain and distention, flatulence, rumbling, and overall gastrointestinal (GI) symptoms (except dissatisfaction with bowel habits) was observed in the patients receiving vitamin D as compared to the placebo group. The IBSSS and the IBS-QoL scores in the vitamin D group significantly improved compared to the placebo group postintervention (mean IBSSS score change: -53.82 ± 23.3 vs -16.85 ± 25.01, p < 0.001, respectively; mean IBS-QoL score change: 14.26 ± 3 vs 11 ± 2.34, p < 0.001, respectively).

CONCLUSIONS & INFERENCES: 

Vitamin D seems to be an effective and safe option to improve QoL and symptoms of IBS. ClinicalTrials.gov (NCT02579902).

© 2016 John Wiley & Sons Ltd.

KEYWORDS: 

IBS severity score; gastrointestinal symptoms; health-related quality of life; irritable bowel syndrome; vitamin D

PMID:
 
27154424
 
DOI:
 
10.1111/nmo.12851
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