Jeffrey Roberts Posted April 2, 2019 Report Share Posted April 2, 2019 This briefly describes the differences between Zelnorm (tegaserod) and Motegrity (prucalopride) for IBS-C and chronic constipation, as both medications are very similar. Both medications are 5-HT4 serotonin receptor agonists, meaning that they increase the amount of serotonin in the bowel which then causes the bowel to move, causing a spontaneous bowel movement. Zelnorm is approved for IBS-C for women under the age of 65. Motegrity is approved for Chronic Constipation sufferers for both women and men. Zelnorm has the potential risk of cardiac events, albeit it's a small risk that is rarely seen. Motegrity does not have the risk of cardiac events. Zelnorm was previously marketed from 2002-2007 in the US and elsewhere. Motegrity has been widely available worldwide except in the US, since 2009. Link to comment Share on other sites More sharing options...
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