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Pubmed-Experience and clinical efficacy of gut-directed hypnotherapy in an Asian population with refractory irritable bowel syndrome

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JGH Open. 2022 May 19;6(7):447-453. doi: 10.1002/jgh3.12770. eCollection 2022 Jul.


BACKGROUND AND AIM: Recent studies have highlighted the high worldwide prevalence of irritable bowel syndrome (IBS) and disparities in its management between ethnic groups. For instance, gut-directed hypnotherapy (GDH), one of the most effective evidence-based treatments for IBS, is not recommended in Asian countries partly due to lack of population-specific outcome data. In this context, we evaluated the outcomes of GDH in an Asian population.

METHODS: Consecutive British Asian patients with refractory IBS who received 12-sessions of GDH using the Manchester protocol were included. Patients were treated by a team including a therapist able to speak several Asian languages. All patients prospectively completed the following questionnaires before and after GDH: IBS symptom severity score (IBS-SSS), hospital anxiety and depression scale (HADS), non-colonic symptom score, and the quality-of-life (QOL) score. The primary outcome measure was response to GDH defined by ≥50-point reduction in IBS-SSS. Pre- and post-treatment data were compared statistically.

RESULTS: Forty-four Asian patients with IBS (age 49 ± 13 years; 29 [66%] female; baseline IBS-SSS: 332.8 ± 94.6) completed GDH. Overall, 37 of 44 (84%) achieved a ≥50-point reduction in IBS-SSS and 25 of 44 (57%) achieved ≥30% reduction in abdominal pain scores. Following GDH, there were also significant mean improvements in IBS-SSS (-132.1, P < 0.0001), non-colonic symptom score (P < 0.0001), QOL score (P < 0.0001), HADS-anxiety (P < 0.0001), and HADS-depression (P < 0.0001), compared with baseline.

CONCLUSION: Regardless of the ethnicity of the therapist, GDH was highly effective with similar response rates to outcomes in other IBS populations, supporting the development of GDH in Asian countries.

PMID:35822122 | PMC:PMC9260202 | DOI:10.1002/jgh3.12770

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