Miki Posted September 22, 2022 Report Share Posted September 22, 2022 I started taking Motegrity 1mg at night at least five hours after eating and it just doesn't work. Tons of side effects though. I have tried this a decade ago and had side effects but at least it worked a little. Would it work better in the morning? I have a feeling 2mg is what I need but I do understand the conservative approach. I guess there isn't any point if I just feel like I took something funny, but not going to the bathroom. I did what my doctor calls a "Holiday" first. In other words, I did not go straight from Zelnorm to Motegrity because I remember when I first took it I was told they both build up in your system the same way and you have to take someting else for a few weeks to have it work again. There is nothing like feeling like something is going to work and it just doesn't. Any advice is much appreciated! Quote Link to comment Share on other sites More sharing options...
Jeffrey Roberts Posted September 23, 2022 Report Share Posted September 23, 2022 I have heard from gastroenterologists saying that nothing seems to work the same as Zelnorm. Although Motegrity is a similar compound, you are probably going to have to play with it for a while until you find the right dosage at the right time. So little info on how people are coping with Motegrity that I don't have any other advice to offer. Please keep us posted how you are doing. Quote Link to comment Share on other sites More sharing options...
Miki Posted September 23, 2022 Author Report Share Posted September 23, 2022 Thanks for letting me know. I decided to take it in the morning and increase to 1 1/2 mg. I know that I should not change two things but it is crazy how this can cause so many side effects and not work. It worked for me a little when I took 1mg Resolor about 10 years ago. Is this made by the same company? Quote Link to comment Share on other sites More sharing options...
Jeffrey Roberts Posted September 23, 2022 Report Share Posted September 23, 2022 It's really hard to know whether Resolor/Resotran is manufactured in the same facility as Motegrity. They are marketed by different pharmaceuticals. You'd really think that all 5-HT4 medications were a like so I find this very fascinating. Quote Link to comment Share on other sites More sharing options...
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