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Google-Linzess safely improves bowel movement, consistency in pediatric functional constipation - Healio


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Linzess safely improves bowel movement, consistency in pediatric functional constipation  Healio

Ironwood Pharmaceuticals Inc. announced positive results from its phase 3 trial that evaluated Linzess for the treatment of pediatric patients with functional constipation, according to a company press release.

In a randomized, double-blind, parallel group study, 330 pediatric patients with functional constipation aged 6 to 17 years received either Linzess (linaclotide 72 mcg, AbbVie/Ironwood) or placebo. In a Healio interview exclusive, Susanna Huh, MD, MPH, head of clinical development and research for Ironwood Pharmaceuticals, said Linzess induced a “statistically significant and clinically meaningful improvement compared with placebo in 12-week spontaneous bowel movement frequency,” and a greater than two-fold least squares mean change from baseline per week compared with placebo. Researchers also observed improved stool consistency.

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