Colesevelam boosts likelihood for clinical remission in patients with ... - Healio

[Health Reporter]

Colesevelam boosts likelihood for clinical remission in patients with ...  Healio

Colesevelam was superior to placebo in inducing remission in patients with bile acid diarrhea with no serious adverse events reported, according to results published in The Lancet Gastroenterology & Hepatology.

“Bile acid diarrhea is a common yet underrecognized cause of chronic watery diarrhea. In most countries, including the U.S., the diagnostic nuclear medicine tauroselcholic [Se] acid (SeHCAT) retention test is unavailable. The biochemical Plasma 7alpha-hydroxy-4-cholesten-3-one (C4) test has lower sensitivity compared with SeHCAT but is much cheaper and potentially widely available,” Christian Borup, MD,of Zealand University Hospital in Denmark, told Healio. “Treatment with bile acid binding sequestrants such as colestyramine, colestipol and colesevelam appears effective in observational studies, but the few placebo-controlled trials were underpowered to show superiority over placebo regarding bowel symptoms.

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