Jump to content

High GI symptom burden in Fabry disease unrelated to gut motility problems - Fabry Disease News


Health Reporter

Recommended Posts

High GI symptom burden in Fabry not linked to gut motility problems  Fabry Disease News

Problems may be tied to dysfunction in nerve cells that control gut reflexes

image.png

Problems moving food through the gastrointestinal system didn’t largely account for gastrointestinal (GI) symptoms in Fabry disease patients, a recent study shows.

The symptoms, which have an impact on patients’ quality of life, may instead arise from dysfunction in the nerve cells that control gut reflexes.

The study, “Gastrointestinal sensory neuropathy and dysmotility in Fabry disease: Presentations and effect on patient’s quality of life,” was published in Clinical and Translational Gastroenterology.

People with Fabry disease are deficient in alpha-galactosidase A (Gal A), an enzyme that breaks down certain fatty molecules in cells. As a result, the molecule accumulates to toxic levels and disrupts the function of various organ systems.

GI issues are among the disease’s symptoms and may include diarrhea, constipation, abdominal pain, and nausea, among other manifestations.

View the full article

Link to comment
Share on other sites

  • Jeffrey Roberts changed the title to High GI symptom burden in Fabry disease unrelated to gut motility problems - Fabry Disease News
×
×
  • Create New...