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Non-prescription therapeutics for IBS: where are we? - Gut Microbiota for Health


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Non-prescription therapeutics for IBS: where are we?  Gut Microbiota for Health

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Irritable Bowel Syndrome (IBS) is recognized as a chronic, multifaceted disorder of gut-brain interaction (DGBI), characterized by recurrent abdominal pain related to defecation and may be associated with changes in bowel habits (diarrhea or constipation).1

The intestinal microbiota is suggested to be an underlying element explaining key pathophysiological alterations well described and studied in IBS, such as visceral hypersensitivity, impaired intestinal barrier function, altered intestinal secretion, and activation of the mucosal immune system with low-grade inflammatory response.2 This is supported not only by the known role of an acute infectious event in PI-IBS development but also by multiple pieces of evidence that gut microbiota modifying treatments (e.g., prebiotics, probiotics, antibiotics, or fecal microbiota transplantation) can improve IBS symptoms without significant side effects.3

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  • Jeffrey Roberts changed the title to Non-prescription therapeutics for IBS: where are we? - Gut Microbiota for Health
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