Jump to content

Pubmed-Cryptosporidium and irritable bowel syndrome

Health Reporter

Recommended Posts

Trop Parasitol. 2024 Jan-Jun;14(1):8-15. doi: 10.4103/tp.tp_10_23. Epub 2024 Feb 15.


Cryptosporidium is an apicomplexan parasite that causes gastrointestinal disease in a wide variety of hosts and is associated with waterborne outbreaks. Nonetheless, the parasite is underdiagnosed. Cryptosporidium has been proposed as an etiological cause of irritable bowel syndrome (IBS) in several studies. However, the exact mechanism of pathogenesis is unknown, and no direct link has been discovered. This review will discuss several parasite-induced modifications, such as immunological, microbiome, and metabolite modifications, as well as their interactions. To summarize, Cryptosporidium causes low inflammation, dysbiosis, and unbalanced metabolism, which leads to a lack of homeostasis in the intestine in a comparable pattern to postinfectious IBS.

PMID:38444793 | PMC:PMC10911187 | DOI:10.4103/tp.tp_10_23

View the full article

Link to comment
Share on other sites

  • Create New...