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Updated: 1 hour 59 min ago

Twitter-RT @AliRezaieMD: Proud to see that GI division @CedarsSinai is ranked #1 in California and #3 in the country on @usnews #BestHospitals rank…

12 hours 42 min ago
RT @AliRezaieMD: Proud to see that GI division @CedarsSinai is ranked #1 in California and #3 in the country on @usnews #BestHospitals rank… (RSS generated with FetchRss) View the full article

Twitter-IBS—From Symptom to Disease: Five Things to Know | Gastro Girl https://t.co/Ik1fRwJUvj

13 hours 9 min ago
IBS—From Symptom to Disease: Five Things to Know | Gastro Girl https://gastrogirl.com/2018/07/30/ibs-from-symptom-to-disease-five-things-to-know/ (RSS generated with FetchRss) View the full article

Pubmed-Vaccinations in immunosuppressive-dependent pediatric inflammatory bowel disease.

17 hours 55 min ago
Related Articles Vaccinations in immunosuppressive-dependent pediatric inflammatory bowel disease. World J Gastroenterol. 2017 Nov 14;23(42):7644-7652 Authors: Nguyen HT, Minar P, Jackson K, Fulkerson PC Abstract AIM: To determine the vaccination rates in pediatric immunosuppression-dependent inflammatory bowel disease (IBD) and review the safety and efficacy of vaccinations in this population. METHODS: The electronic medical records from October 2009 to December 2015 of patients diagnosed with IBD at 10 years of age or younger and prescribed anti-tumor necrosis factor alpha (anti-TNF-α) therapy were reviewed for clinical history, medication history, vaccination history, and hepatitis B and varicella titers. Literature discussing vaccination response in IBD patients were identified through search of the MEDLINE database and reviewed using the key words "inflammatory bowel disease", "immunization", "vaccination", "pneumococcal", "varicella", and "hepatitis B". Non-human and non-English language studies were excluded. Search results were reviewed by authors to select articles that addressed safety and efficacy of immunizations in inflammatory bowel disease. RESULTS: A total of 51 patients diagnosed with IBD prior to the age of 10 and receiving anti-TNF-α therapy were identified. Thirty-three percent of patients (17/51) had incomplete or no documentation of vaccinations. Sixteen case reports, cohort studies, cross-sectional studies, and randomized trials were determined through review of the literature to describe the safety and efficacy of hepatitis B, pneumococcal, and varicella immunizations in adult and pediatric patients with IBD. These studies showed that patients safely tolerated the vaccines without significant adverse effects. Importantly, IBD patients receiving immunosuppressive medications, particularly anti-TNF-α treatment, have decreased vaccine response compared to controls. However, the majority of patients are still able to achieve protective levels of specific antibodies. CONCLUSION: Immunizations have been shown to be well-tolerated and protective immunity can be achieved in patients with IBD requiring immunosuppressive therapy. PMID: 29204064 [PubMed - indexed for MEDLINE] View the full article

Pubmed-Coeliac disease.

17 hours 55 min ago
Related Articles Coeliac disease. Paediatr Int Child Health. 2018 Aug 13;:1-9 Authors: Glissen Brown JR, Singh P Abstract Coeliac disease (CD) develops in genetically susceptible individuals who, in response to unclear environmental triggers, develop an immune response triggered by gluten ingestion. It is now recognised as a global disease affecting about 0.7% of the world's population. The clinical presentation ranges from malabsorption to asymptomatic individuals diagnosed by screening high-risk groups. Diagnosis requires the demonstration of small intestinal villous atrophy in the presence of circulating coeliac auto-antibodies and/or an unequivocal response to a gluten-free diet (GFD). Recent guidelines suggest that, in a subset of children, duodenal biopsies can be avoided in the presence of strict symptomatic and serological criteria. While the majority of patients respond to a GFD, up to 20% of patients with CD have persistent or recurrent symptoms. There are several aetiologies for residual or new symptoms in a patient with CD on a GFD, with inadvertent exposure to gluten being the most common. Following a GFD can be challenging for patients with CD and understanding the barriers/challenges faced by patients in maintaining a GFD is crucial for compliance. ABBREVIATIONS: AGA: anti-gliadin antibodies; Anti-DGP-ab: anti-deamidated gliadin peptide antibodies; Anti-tTG-ab: anti-tissue transglutaminase antibodies; ATD: auto-immune thyroid disorders; BMD: bone mineral density; CD: coeliac disease; DH: dermatitis herpetiformis; EMA: anti-endomysial antibodies; FDR: first-degree relatives; GFD: gluten-free diet; HbA1c: haemoglobin A1c; HLA: human leucocyte antigen; IBS: irritable bowel syndrome; LMIC: low- and middle-income countries; NPV: negative predictive value; NRCD: non-responsive coeliac disease; POCT: point-of-care tests; SDR: second-degree relatives; SIBO: small intestinal bacterial overgrowth; T1DM: type 1 diabetes mellitus; ULN: upper limit of normal. PMID: 30099930 [PubMed - as supplied by publisher] View the full article

Pubmed-Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease.

17 hours 55 min ago
Related Articles Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease. J Dairy Sci. 2018 Aug 09;: Authors: Seo MK, Park EJ, Ko SY, Choi EW, Kim S Abstract Kefir is a fermented product from yeast and lactic acid bacteria, and has been associated with various health benefits including relieving inflammatory bowel disease. Recently, it has been shown that gram-positive bacteria produce extracellular vesicles (EV). The EV could be appearing as potentially important mediators of cell to cell interaction. In this study, we explored the role of kefir grain Lactobacillus-derived EV in modulating inflammation responses via alleviating the production of inflammatory cytokines in tumor necrosis factor-α (TNF-α)-induced inflammation in Caco-2 cells and the 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease mouse model. Kefir-derived Lactobacillus EV were isolated by ultracentrifugation of the culture medium of 3 different kefir-derived strains (i.e., Lactobacillus kefir, Lactobacillus kefiranofaciens, and Lactobacillus kefirgranum). Nanoparticle tracking analysis showed that the size of isolated kefir-derived Lactobacillus EV was within 80 to 400 nm, and kefir-derived Lactobacillus EV uptake into recipient Caco-2 cells was confirmed by fluorescence labeling. Treatment of each kefir-derived Lactobacillus EV onto TNF-α-stimulated Caco-2 cells significantly reduced the level of both mRNA expression and secretion of IL-8, and Western blot analysis revealed that such an effect was related to inhibition of TNF-α signaling mediated by reducing the phosphorylation of p65, a subunit of NF-kB. Subsequent administration of kefir-derived Lactobacillus EV into inflammatory bowel disease-induced mice significantly alleviated the body weight loss and rectal bleeding, and enhanced stool consistency. Histological examination showed that kefir-derived Lactobacillus EV substantially reduced the infiltration of transmural leukocytes and loss of goblet cells within the colon, and the serum level of myeloperoxidase was significantly lower in the EV-treated group than control group. Our study demonstrates that kefir-derived Lactobacillus EV can be potentially used for developing innovative strategies for alleviating inflammatory bowel disease. PMID: 30100498 [PubMed - as supplied by publisher] View the full article

Pubmed-Is Henoch-Schönlein purpura a susceptibility factor for functional gastrointestinal disorders in children?

17 hours 55 min ago
Related Articles Is Henoch-Schönlein purpura a susceptibility factor for functional gastrointestinal disorders in children? Rheumatol Int. 2018 Aug 12;: Authors: Kisla Ekinci RM, Balcı S, Mart OO, Tumgor G, Yavuz S, Celik H, Dogruel D, Altintas DU, Yilmaz M Abstract Henoch-Schönlein purpura (HSP), the most common childhood vasculitis is characterized by non-thrombocytopenic palpable purpura, arthritis/arthralgia, abdominal pain and renal involvement. Functional gastrointestinal disorders (FGIDs) are heterogeneous disease spectrum with unclear etiology and include the most common subtypes: functional dyspepsia, irritable bowel syndrome (IBS), functional abdominal pain and functional constipation. Formerly, FGIDs were known as non-organic disorders; however, recent advances revealed that low-grade inflammation may also play a role. We aimed to clarify whether HSP predisposes to FGIDs in pediatric population. Seventy-four children with HSP, diagnosed at least 6 months before the study and 78 healthy controls were enrolled to the study. Patients with red flag signs for organic GI disorders were excluded. Rome IV criteria were utilized for FGIDs diagnosis. We compared the frequencies of FGIDs between HSP patients and healthy subjects. We also examined the parameters including age, abdominal pain, arthralgia, bloody stool, renal involvement and treatment with corticosteroids and laboratory results at HSP diagnosis such as erythrocyte sedimentation rate, C-reactive protein, hemoglobin, leukocytes and platelet counts among patients with and without FGIDs. Overall FGIDs and IBS frequency were 35.1% (n = 26) and 10.8% (n = 8) in HSP patients, 19.2% (n = 15) and 2.6% (n = 2) in healthy controls, respectively. Disease characteristics and laboratory parameters at disease onset were similar between HSP patients with and without FGIDs. Overall FGIDs rate, particularly IBS were statistically higher in HSP patients. We speculate that children with preceding HSP may be predisposed to FGIDs. Since the FGIDs pathogenesis is still remains unclear, further studies are needed to confirm this hypothesis and clarify the etiology. Physicians also should pay attention to FGIDs in HSP patients with ongoing abdominal pain and thus prevent this comorbidity with dietary and psychologic measures. PMID: 30101368 [PubMed - as supplied by publisher] View the full article

Pubmed-The central effects of buspirone on abdominal pain in rats.

17 hours 55 min ago
Related Articles The central effects of buspirone on abdominal pain in rats. Neurogastroenterol Motil. 2018 Aug 13;:e13431 Authors: Panteleev SS, Sivachenko IB, Lyubashina OA Abstract BACKGROUND: Buspirone, a partial agonist of the 5-HT1a receptor (5-HT1a R), owing to potential antinociceptive properties may be useful in treatment of abdominal pain in IBS patients. The pain-related effects of buspirone are mediated via the 5-HT1a Rs, specifically located within the ventrolateral medulla (VLM). The most animal studies of the 5-HT1a R involvement in pain control have been carried out with somatic behavioral tests. The 5-HT1a R contribution in visceral pain transmission within the VLM is unclear. The objective of our study was to evaluate the 5-HT1a R contribution in abdominal pain transmission within the VLM. METHODS: Using animal model of abdominal pain (urethane-anaesthetized rats), based on the noxious colorectal distension (CRD) as pain stimulus we studied effects of buspirone (1.0-4.0 mg kg-1 , iv) on the CRD-induced VLM neuron and blood pressure responses as markers of abdominal pain before and after the 5-HT1a R blockade by antagonist, WAY 100,635. RESULTS: The CRD induced a significant increase in VLM neuron activity up to 201.5 ± 18.0% and depressor reactions up to 68 ± 1.8% of baseline. Buspirone (1.0-4.0 mg kg-1 , iv) resulted in an inhibition of the CRD-induced neuron responses which were changed inversely with dose increase and decreased depressor reactions directly with dose increase. These effects were antagonized by intracerebroventricular WAY 100,635. CONCLUSION: Buspirone exerts complex biphasic action on the pain-related VLM neuron activity inversely depending on dose. The final effect of buspirone depends on the functional balance between of activation the pre- and postsynaptic 5-HT1a Rs in mediating pain control networks. PMID: 30101506 [PubMed - as supplied by publisher] View the full article

Pubmed-Enzyme therapy for functional bowel disease-like post-prandial distress.

17 hours 55 min ago
Related Articles Enzyme therapy for functional bowel disease-like post-prandial distress. J Dig Dis. 2018 Aug 13;: Authors: Graham DY, Ketwaroo GA, Money ME, Opekun AR Abstract Post-prandial gastrointestinal symptoms such as diarrhea, abdominal distension, flatulence, bloating, and feeling of fullness are common complaints of often unknown etiology and pathogenesis. There is a long history of trials reporting successful use of products containing a variety of combinations of digestive enzymes including a number of randomized placebo-controlled trials. We provide a narrative review of studies describing the use of multi-digestive enzymes for symptoms consistent with the irritable bowel syndrome. We describe clinical trials reported over the past 60 years including double-blinded randomized, placebo-controlled studies including recent trials that focused on post-prandial diarrhea consistent with diarrhea-predominant irritable bowel syndrome. Disaccharidase deficiencies or deficiencies of other carbohydrate digesting enzymes were excluded. Worldwide studies have generally reported success with multi-enzyme preparations although none used a factorial design to identify subgroups or attempted to link specific symptom responses to specific components of therapy. Although there is a long history of successful use of multi-enzyme preparation for post-prandial symptoms consistent with the irritable bowel syndrome, long-term studies using validated scoring systems and factorial designs are needed to confirm the results in relation to specific symptoms and the components of the combination drugs received. This article is protected by copyright. All rights reserved. PMID: 30101562 [PubMed - as supplied by publisher] View the full article

Pubmed-Unmet needs of patients with irritable bowel syndrome.

17 hours 55 min ago
Unmet needs of patients with irritable bowel syndrome. Lancet Gastroenterol Hepatol. 2018 Sep;3(9):587 Authors: The Lancet Gastroenterology Hepatology PMID: 30102176 [PubMed - in process] View the full article

Pubmed-The associated features of multiple somatic symptom complexes.

Aug 13, 2018
Related Articles The associated features of multiple somatic symptom complexes. J Psychosom Res. 2018 Sep;112:1-8 Authors: Creed F, Tomenson B, Chew-Graham C, Macfarlane G, McBeth J Abstract OBJECTIVE: To assess whether two or more functional somatic symptom complexes (SSCs) showed stronger association with psychosocial correlates than single or no SSC after adjustment for depression/anxiety and general medical disorders. METHODS: In a population-based sample we identified, by standardised questionnaire, participants with chronic widespread pain, chronic fatigue and irritable bowel syndrome, excluding those with a medical cause for pain/fatigue. We compared psychosocial variables in three groups: multiple (>1), single or no FSS, adjusting for depression/anxiety and general medical disorders using ordinal logistic regression. We evaluated whether multiple SSCs predicted health status 1 year later using multiple regression to adjust for confounders. RESULTS: Of 1443 participants (58.0% response) medical records were examined in 990: 4.4% (n = 44) had 2 or 3 symptom complexes, 16.2% a single symptom complex. Many psychosocial adversities were significantly associated with number of SSCs in the expected direction but, for many, statistical significance was lost after adjustment for depression/anxiety and medical illness. Somatic symptoms, health anxiety, impairment and number of prior doctor visits remained significantly associated. Impaired health status 1 year later was predicted by multiple somatic symptom complexes even after adjustment for depression, anxiety, medical disorders and number of symptoms. CONCLUSIONS: Depression, anxiety, medical illness and health anxiety, demonstrated an exposure-response relationship with number of somatic symptom complexes. These may be core features of all Functional Somatic Syndromes and may explain why number of somatic symptom complexes predicted subsequent health status. These features merit inclusion in prospective studies to ascertain causal relationships. PMID: 30097128 [PubMed - in process] View the full article

Google-Constipation Linked to Unusually Frequent ED Visits by Children With Autism

Aug 13, 2018
Constipation Linked to Unusually Frequent ED Visits by Children With Autism Gastroenterology & Endoscopy News Full coverage View the full article

Twitter-“Further research should aim to understand when to introduce prescription options & physiologic testing to identify patients with outlet obstruction constipation who would not be expected to improve with laxatives or fiber.”-@umfoodoc https://

Aug 13, 2018
“Further research should aim to understand when to introduce prescription options & physiologic testing to identify patients with outlet obstruction constipation who would not be expected to improve with laxatives or fiber.”-@umfoodoc https://twitter.com/gastroendonews/status/1027249447938478080 (RSS generated with FetchRss) View the full article

Twitter-RT @OPBMed: This got me thinking, what indirect ways has your chronic digestive illness has affected your life? Something not blatantly obv…

Aug 13, 2018
RT @OPBMed: This got me thinking, what indirect ways has your chronic digestive illness has affected your life? Something not blatantly obv… (RSS generated with FetchRss) View the full article

Google-Your toilet sitting position is giving you constipation! Know how to correct it

Aug 13, 2018
Your toilet sitting position is giving you constipation! Know how to correct it Times of India Full coverage View the full article

Twitter-Want to broaden your horizons when it comes to #lowFODMAP grain & cereal options? See here for tips: https://t.co/UjYAyfd6BT https://t.co/620q2Ox5Ks

Aug 12, 2018
Want to broaden your horizons when it comes to #lowFODMAP grain & cereal options? See here for tips: https://www.monashfodmap.com/blog/using-non-traditional-cereals-and-grains/ (RSS generated with FetchRss) View the full article

Twitter-Thanks for the feedback. This is possible for up to 80% of people with IBS who follow a low #FODMAP diet as faithfully as they can during the elimination phase! #IBS #smiling https://t.co/qYq68YWFDH

Aug 11, 2018
Thanks for the feedback. This is possible for up to 80% of people with IBS who follow a low #FODMAP diet as faithfully as they can during the elimination phase! #IBS #smiling https://twitter.com/flacchy/status/1028169693495021569 (RSS generated with FetchRss) View the full article

Twitter-The Poop museum in Tokyo, Japan https://t.co/da34dxLYJO

Aug 11, 2018
The Poop museum in Tokyo, Japan https://smartenings.com/the-poop-museum-in-tokyo/ (RSS generated with FetchRss) View the full article

Twitter-Wondering what to do when a food is not in the app? Why not try testing your own tolerance! https://t.co/ld75u9UvGV https://t.co/BKnAmqT4kP

Aug 11, 2018
Wondering what to do when a food is not in the app? Why not try testing your own tolerance! http://ow.ly/ZL9C30l1bEW (RSS generated with FetchRss) View the full article

Twitter-RT @pediRD: Got a child with GI issues? Heard about the Low FODMAP diet? Kate Scarlata puts the two together in this episode of The Nourish…

Aug 11, 2018
RT @pediRD: Got a child with GI issues? Heard about the Low FODMAP diet? Kate Scarlata puts the two together in this episode of The Nourish… (RSS generated with FetchRss) View the full article

Twitter-Get to know your #gut bugs! An excellent introduction to the #microbiome here: https://t.co/iIwQCsNYNA https://t.co/bdXfQAO2e2

Aug 11, 2018
Get to know your #gut bugs! An excellent introduction to the #microbiome here: http://bit.ly/2xr8FVK (RSS generated with FetchRss) View the full article

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