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Twitter-RT @HHSGov: If someone you know is struggling emotionally or having a hard time, you can be the difference in getting them the help they ne…

Sep 10, 2018
RT @HHSGov: If someone you know is struggling emotionally or having a hard time, you can be the difference in getting them the help they ne… (RSS generated with FetchRss) View the full article

Twitter-RT @US_FDA: FDA will hold a public meeting in November for stakeholders to provide input on the underlying systemic causes of drug shortage…

Sep 10, 2018
RT @US_FDA: FDA will hold a public meeting in November for stakeholders to provide input on the underlying systemic causes of drug shortage… (RSS generated with FetchRss) View the full article

Google-Dr Cathy Stephenson: Constipation and what to do about it

Sep 10, 2018
Dr Cathy Stephenson: Constipation and what to do about it Stuff.co.nz Full coverage View the full article

Pubmed-Influence of Early Life, Diet, and the Environment on the Microbiome.

Sep 10, 2018
Influence of Early Life, Diet, and the Environment on the Microbiome. Clin Gastroenterol Hepatol. 2018 Sep 06;: Authors: Dong TS, Gupta A Abstract Advances in sequencing technology and bioinformatics have greatly enhanced our ability to understand the human microbiome. Over the last decade, a growing body of literature has linked nutrition and the environment to the microbiome and is now thought to be an important contributor to overall health. This paper reviews the literature from the past 10 years to highlight the influence of environmental factors such as diet, early life adversity and stress in shaping and modifying our microbiome towards health and disease. The review shows that many factors such as the mode of delivery, breast milk, stress, diet and medications can greatly influence the development of our gut microbiome and potentially make us more prone to certain diseases. By incorporating environmental factors into models that study the microbiome in the setting of health and disease, may provide a better understanding of disease and potentially new areas of treatment. To highlight this, we will additionally explore the role of the environment and the microbiome in the development of obesity and functional bowel disorders. PMID: 30196160 [PubMed - as supplied by publisher] View the full article

Twitter-RT @FodyFoods: This Low FODMAP Pesto Pasta with Grilled Chicken and Roasted Tomatoes is the perfect way to end off your weekend . ROASTED T…

Sep 9, 2018
RT @FodyFoods: This Low FODMAP Pesto Pasta with Grilled Chicken and Roasted Tomatoes is the perfect way to end off your weekend . ROASTED T… (RSS generated with FetchRss) View the full article

Twitter-The symptoms of coeliac disease can be misdiagnosed for IBS, however undiagnosed coeliac disease can have massive health implications. Read about the tests for Coeliac Disease here in the Australian Journal of General Practice: https://t.co/Lu8Cp

Sep 9, 2018
The symptoms of coeliac disease can be misdiagnosed for IBS, however undiagnosed coeliac disease can have massive health implications. Read about the tests for Coeliac Disease here in the Australian Journal of General Practice: https://bit.ly/2oB4BLV (RSS generated with FetchRss) View the full article

Pubmed-Computer-Assisted Cognitive-Behavior Therapy in Medical Care Settings.

Sep 9, 2018
Related Articles Computer-Assisted Cognitive-Behavior Therapy in Medical Care Settings. Curr Psychiatry Rep. 2018 Sep 07;20(10):92 Authors: Wright JH, McCray LW, Eells TD, Gopalraj R, Bishop LB Abstract PURPOSE OF REVIEW: We reviewed research on computer-assisted cognitive-behavior therapy (CCBT) performed in medical settings with the goals of assessing the effectiveness of this newer method of treatment delivery, evaluating the need for clinician support of therapeutic computer programs, and making suggestions for future research and clinical implementation. RECENT FINDINGS: The overall results of randomized, controlled trials suggest that CCBT can be an effective treatment for depression in primary care patients and health care anxiety. Also, it can be a useful component of treatment for somatic conditions including irritable bowel syndrome, diabetes, fibromyalgia, and chronic pain. The amount and type of clinician support needed for maximizing effectiveness remains unclear. CCBT offers promise for overcoming barriers to delivering effective psychotherapy in medical settings. We recommend that next steps for researchers include more definitive studies of the influence of clinician support, investigations focused on implementation in clinical practices, cost-benefit analyses, and use of technological advances. PMID: 30194498 [PubMed - in process] View the full article

Pubmed-Review article: an analysis of safety profiles of the treatments for diarrhoea-predominant irritable bowel syndrome.

Sep 9, 2018
Related Articles Review article: an analysis of safety profiles of the treatments for diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2018 Sep 07;: Authors: Lacy BE Abstract BACKGROUND: Irritable bowel syndrome (IBS) is multifactorial in nature, and a wide range of therapies are available to manage symptoms of this common disorder. AIM: To provide an overview of the safety of interventions that may be used to manage patients with diarrhoea-predominant IBS (IBS-D). METHODS: Medline and Embase database searches (through 02 May 2018) to identify clinical studies that evaluated treatment safety and/or efficacy in adults with IBS-D. RESULTS: IBS-D treatments include dietary modification, probiotics, serotonin receptor antagonists, opioid receptor agonists and antagonists, nonsystemic antibiotics, bile acid sequestrants, antidepressants, and complementary and alternative therapies. These treatments vary in administration frequency (eg, daily; short-course therapy) and target various pathophysiologic factors. Safety profiles vary considerably by treatment among IBS-D therapies. The number needed to harm (defined as the number of patients treated to encounter an adverse event) was lowest (worse) for antidepressants (8.5) and highest (best) for probiotics (35), and the number needed to harm (defined as the number of patients who discontinued due to an adverse event) was lowest for tricyclic antidepressants (9) and highest for rifaximin (8971). Notable safety concerns with IBS-D treatments include pancreatitis with eluxadoline, ischaemic colitis and serious complications of constipation with alosetron, and cardiac adverse events with loperamide and tricyclic antidepressants. Treatment decisions need to account for medication risks and adverse events for each patient. CONCLUSIONS: Multiple treatment options are now available for patients with IBS-D. However, the safety profiles of these agents vary widely by number needed to harm value. Providers should consider both safety and efficacy of a specific intervention when determining how best to manage patients' IBS-D symptoms. PMID: 30194692 [PubMed - as supplied by publisher] View the full article

Twitter-RT @GiHFoundation: Interview with Jill Olmstead at #GHAPP18. https://t.co/YyTbqhpSxj

Sep 8, 2018
RT @GiHFoundation: Interview with Jill Olmstead at #GHAPP18. https://youtu.be/KrPbl0kCAxo (RSS generated with FetchRss) View the full article

Twitter-RT @doctorira: on the other hand, super excited that @umfoodoc will be joining me Monday to talk #IBS and more on @nyudocs @siriusXM!

Sep 8, 2018
RT @doctorira: on the other hand, super excited that @umfoodoc will be joining me Monday to talk #IBS and more on @nyudocs @siriusXM! (RSS generated with FetchRss) View the full article

Twitter-We do our best to test a wide variety of foods for our Monash FODMAP App but you will no doubt come across foods you can't find in our app. So what do you do when you come across an untested food? Read our blog here: https://t.co/1LcbmD9XKF https:

Sep 8, 2018
We do our best to test a wide variety of foods for our Monash FODMAP App but you will no doubt come across foods you can't find in our app. So what do you do when you come across an untested food? Read our blog here: https://bit.ly/2hTWsyC (RSS generated with FetchRss) View the full article

Twitter-How Common Is Magnesium Deficiency—and Could You Have It? https://t.co/mqlzrIuOan via @CookingLight

Sep 8, 2018
How Common Is Magnesium Deficiency—and Could You Have It? https://www.cookinglight.com/syndication/magnesium-deficiency?utm_source=twitter.com&utm_medium=social&utm_campaign=social-button-sharing via @CookingLight (RSS generated with FetchRss) View the full article

Pubmed-Fecal incontinence in people with self-reported irritable bowel syndrome: Prevalence and quality of life.

Sep 8, 2018
Related Articles Fecal incontinence in people with self-reported irritable bowel syndrome: Prevalence and quality of life. J Psychosom Res. 2018 Oct;113:45-51 Authors: Hunt MG, Wong C, Aajmain S, Dawodu I Abstract Irritable bowel syndrome (IBS) is a common functional gastrointestinal (GI) disorder characterized by recurrent abdominal pain and altered bowel habits. IBS is a risk factor for fecal incontinence (FI), the unintentional passage of solid or liquid stool. FI can substantially interfere with health related quality of life (HRQL), leading to heightened anxiety and avoidance behavior. Nevertheless, relatively little research has been conducted on the prevalence of FI in IBS patients. This study evaluated the prevalence of FI in people with self-reported IBS and the relationship between FI and HRQL. 703 people who reported a diagnosis of IBS completed questionnaires on IBS symptom severity, FI symptom severity, HRQL, fear of food, anxiety about visceral sensations, and GI specific catastrophizing. Overall, 60% of people with IBS reported experiencing at least one lifetime episode of FI. In a subsample of 360 people who met strict Rome IV criteria and reported no other GI related co-morbidities, 62% reported experiencing at least one lifetime episode. While people who experienced FI more frequently had worse HRQL statistically, the differences in HRQL between people who had experienced FI and those who had not were not clinically significant. Rather than frequency of FI or physical symptom severity, quality of life was mostly determined by psychological variables, such as fear of food, anxiety, and catastrophizing. This study suggests that FI is quite prevalent in IBS patients, but that the best way to improve HRQL for IBS patients with FI may be to focus on reducing anxiety, catastrophizing and avoidance. PMID: 30190047 [PubMed - in process] View the full article

Pubmed-A randomized clinical trial of the Unified Protocol for Transdiagnostic treatment of emotional and gastrointestinal symptoms in patients with irritable bowel syndrome: evaluating efficacy and mechanism of change.

Sep 8, 2018
Related Articles A randomized clinical trial of the Unified Protocol for Transdiagnostic treatment of emotional and gastrointestinal symptoms in patients with irritable bowel syndrome: evaluating efficacy and mechanism of change. J Psychosom Res. 2018 Oct;113:8-15 Authors: Mohsenabadi H, Zanjani Z, Shabani MJ, Arj A Abstract OBJECTIVE: The aim of this randomized controlled trial was to evaluate the efficacy of Unified Protocol (UP) for transdiagnostic treatment of psychological problems, such as anxiety, depression, and stress, and treating the intensity of gastrointestinal symptoms in individuals with Irritable Bowel Syndrome (IBS). Another aim of the study was to test whether emotion regulation mediates the effect of UP. METHODS: Among 91 patients diagnosed with IBS (using ROME III criteria), 64 patients were eligible to participate in the study based on the inclusion/exclusion criteria. These patients were randomly assigned to either an intervention group (n = 32) that participated in 12 weekly UP treatment sessions or to a wait-list control group (n = 32). All patients completed the Depression, Anxiety, and Stress Scale (DASS-42), Emotion Regulation Questionnaire (ERQ), and Gastrointestinal Symptoms Rating Scale (GSRS) pre- and post-intervention. The data were analyzed with SPSS 20.0 software. RESULTS: The results of intention-to-treat (ITT) analysis indicated a significant decrease in depression, anxiety, stress, and gastrointestinal symptoms, as well as significant improvements in emotion regulation scores in the intervention group post intervention. All results were significant at P < .001. Mediation analyses indicated that changes in emotion regulation mediated the effect of UP on changes in emotional and gastrointestinal symptoms. CONCLUSION: UP was effective and influential in emotion regulation among the intervention group and caused a decline in emotional and gastrointestinal symptoms. Hence, this intervention is promising, but larger RCTs are needed to more investigate its efficacy. Future studies could also examine the efficacy of the UP in other medical conditions with co-occurring psychological conditions. The study is registered at the irct.ir database under registration number IRCT2017010431765N1. PMID: 30190053 [PubMed - in process] View the full article

Pubmed-Sniffing out causes of gastrointestinal disorders: a review of volatile metabolomic biomarkers.

Sep 8, 2018
Sniffing out causes of gastrointestinal disorders: a review of volatile metabolomic biomarkers. Biomark Med. 2018 Sep 07;: Authors: Ahmed I, Niaz Z, Ewbank F, Akarca D, Felwick R, Furnari M Abstract Distinct changes can be observed in the odor of human excretions during health and disease. Identifying underlying volatile metabolites responsible for these odorous changes can be correlated with the pathological process within the body. Advances in the technology have enabled us to interpret the volatile signature of these changes in the odor. This has opened a promising area to lay the foundations of a rapid, noninvasive and point of care diagnostic tool. This review explores the diagnostic potential of volatile organic metabolites as novel biomarkers and extends the discussion on the clinical applications of these biomarkers in gastrointestinal disorders. PMID: 30191735 [PubMed - as supplied by publisher] View the full article

Google-Meta-Analysis: Antidepressants, Psychological Tx Ease IBS

Sep 7, 2018
Meta-Analysis: Antidepressants, Psychological Tx Ease IBS Medpage Today - amp Full coverage View the full article

Google-Meta-Analysis: Antidepressants, Psychological Tx Ease IBS

Sep 7, 2018
Meta-Analysis: Antidepressants, Psychological Tx Ease IBS MedPage Today Full coverage View the full article

Google-Assessing the Burden of Opioid-Induced Constipation: In Pursuit of Fast Relief and Minimal Pharmacokinetic Drug ...

Sep 7, 2018
Assessing the Burden of Opioid-Induced Constipation: In Pursuit of Fast Relief and Minimal Pharmacokinetic Drug ... Pain Medicine News Full coverage View the full article

Google-Naldemedine is Safe, Well Tolerated in Treatment of Opioid-Induced Constipation

Sep 7, 2018
Naldemedine is Safe, Well Tolerated in Treatment of Opioid-Induced Constipation Clinical Pain Advisor Full coverage View the full article

Google-Top gastroenterology stories: Believing IBS is a disease of 'anxious women' is 'wrong,' vedolizumab linked to low ...

Sep 7, 2018
Top gastroenterology stories: Believing IBS is a disease of 'anxious women' is 'wrong,' vedolizumab linked to low ... Healio Full coverage View the full article

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