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Twitter-RT @CedarsSinai: "Many of our discoveries are helping grow the pipeline of novel diagnostics and therapeutics available to patients here an…

Dec 28, 2018
RT @CedarsSinai: "Many of our discoveries are helping grow the pipeline of novel diagnostics and therapeutics available to patients here an… (RSS generated with FetchRss) View the full article

Twitter-RT @IBSnetwork: Love this from @DublinDietitian & @paula_mee. Only try a low #FODMAP diet when other #IBS treatments have failed and with t…

Dec 28, 2018
RT @IBSnetwork: Love this from @DublinDietitian & @paula_mee. Only try a low #FODMAP diet when other #IBS treatments have failed and with t… (RSS generated with FetchRss) View the full article

Pubmed-Editorial: Tong-Xie-Yao-Fang (TXYF) for irritable bowel syndrome with diarrhoea (IBS-D)-ancient medicine meets modern study.

Dec 28, 2018
Related Articles Editorial: Tong-Xie-Yao-Fang (TXYF) for irritable bowel syndrome with diarrhoea (IBS-D)-ancient medicine meets modern study. Aliment Pharmacol Ther. 2018 Aug;48(4):485-486 Authors: Vitta S, Sayuk GS PMID: 30588695 [PubMed - in process] View the full article

Pubmed-Editorial: Tong-Xie-Yao-Fang (TXYF) for irritable bowel syndrome with diarrhoea (IBS-D)-ancient medicine meets modern study. Authors' reply.

Dec 28, 2018
Related Articles Editorial: Tong-Xie-Yao-Fang (TXYF) for irritable bowel syndrome with diarrhoea (IBS-D)-ancient medicine meets modern study. Authors' reply. Aliment Pharmacol Ther. 2018 Aug;48(4):486-487 Authors: Chen M, Zheng H, Huang DQ PMID: 30588696 [PubMed - in process] View the full article

Pubmed-Is there an appropriate strategy for treating co-morbid irritable bowel syndrome and bladder pain syndrome?

Dec 28, 2018
Is there an appropriate strategy for treating co-morbid irritable bowel syndrome and bladder pain syndrome? Expert Opin Pharmacother. 2018 Dec 27;:1-4 Authors: Dellis AE, Mozaffari S, Nikfar S, Papatsoris AG, Abdollahi M Abstract INTRODUCTION: Two of the most frequent components of chronic pelvic pain syndrome (CPPS) are irritable bowel syndrome (IBS) and bladder pain syndrome (BPS), characterized by considerable overlapping symptoms and pathophysiology. Currently, its management is challenging meaning there is high the demand for novel efficient therapeutics to aid patient care and to tackle the socioeconomic burden of IBS and BPS. As there are presently no sufficient treatment strategies, identifying the mechanisms that result in their main symptoms is the opportunity for developing appropriate therapies. Areas covered: Herein, the authors explore the potential common treatment strategies for co-morbid IBS and BPS and highlight the absolute need for further research of these deliberating clinical entities. Expert opinion: In the future, the authors summise that the discovery of predictive molecular biomarkers combined with clinical phenotypic categorization will likely allow for more definitive differentiation of patients and thus for better treatment options. Furthermore, it has been suggested that effective IBS treatment strategies would be of great value to co-morbid IBS and BPS therapy. PMID: 30589379 [PubMed - as supplied by publisher] View the full article

Pubmed-Review article: implementation of a diet low in FODMAPs for patients with irritable bowel syndrome-directions for future research.

Dec 28, 2018
Review article: implementation of a diet low in FODMAPs for patients with irritable bowel syndrome-directions for future research. Aliment Pharmacol Ther. 2019 Jan;49(2):124-139 Authors: Mitchell H, Porter J, Gibson PR, Barrett J, Garg M Abstract BACKGROUND: Despite the efficacy of a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) for patients with irritable bowel syndrome, many questions remain unanswered with respect to its clinical implementation. AIM: To review literature to identify, synthesise, and provide direction for future research in the implementation and evaluation of the low FODMAP diet. METHODS: Bibliographical searches were performed in Ovid Medline, CINAHL, Scopus and PubMed from database commencement until September 2018, with search terms focused on the population (irritable bowel syndrome) and intervention of interest (FODMAP). RESULTS: Predictors of response to a low FODMAP diet remain under investigation, with preliminary data supporting faecal microbiota or faecal volatile organic compound profiling. Training of clinicians, and standards for the education of patients about the phases of a low FODMAP diet, as well as the role of Apps, require formal evaluation. There are limited data on the longer term efficacy and safety of the low FODMAP diet with respect to sustained symptom control, effect on quality of life and healthcare utilisation, nutritional adequacy, precipitation of disordered eating behaviours, effects on faecal microbiota and metabolomic markers, and subsequent translation to clinical effects. CONCLUSIONS: Many gaps in implementation of the low FODMAP diet in clinical practice, as well as long-term safety and efficacy, remain for further investigation. PMID: 30589971 [PubMed - in process] View the full article

Pubmed-Exploring the multicomponent synergy mechanism of Banxia Xiexin Decoction on irritable bowel syndrome by a systems pharmacology strategy.

Dec 28, 2018
Exploring the multicomponent synergy mechanism of Banxia Xiexin Decoction on irritable bowel syndrome by a systems pharmacology strategy. J Ethnopharmacol. 2018 Dec 24;: Authors: Li B, Rui J, Ding X, Yang X Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Banxia Xiexin Decoction (BXD) is a representative prescription to regulate spleen and stomach in "Treatise on Febrile Diseases", which has been proven effective for the clinical treatment of irritable bowel syndrome (IBS) in the past decades. However, the active principles and molecular mechanisms involved in BXD against IBS are unknown yet. AIM OF THE STUDY: To reveal multicomponent synergy mechanism of BXD on irritable bowel syndrome, we analysed important components, drug targets and crucial pathways using a systems pharmacology strategy. MATERIALS AND METHODS: Systems pharmacology approach was applied to unfold the potential mechanisms of BXD for irritable bowel syndrome, implicated in ADME screening and text mining, target identification, functional annotation, pathway enrichment analysis and network analysis. Subsequently, molecular docking validated the reliability of the interactions of chemical compounds and targets based on systems pharmacology. RESULTS: The 35 important bioactive ingredients meeting the screening criteria from BXD were selected. Interaction networks of the 16 associated kernel targets with the ingredients were constructed and validated. Network analysis dissected the synergistic effects of the 27 crucial pathways, including inhibiting inflammatory reaction, maintaining intestinal function and improving psychological regulation. CONCLUSIONS: The study presents the interpretation of the molecular mechanisms of BXD in the fight against IBS via multicomponent-target interaction networks. It also provides the promising drug targets and candidate compounds for the development of new combination medicines. PMID: 30590198 [PubMed - as supplied by publisher] View the full article

Pubmed-The association of trace elements with premenstrual syndrome, dysmenorrhea and irritable bowel syndrome in adolescents.

Dec 28, 2018
The association of trace elements with premenstrual syndrome, dysmenorrhea and irritable bowel syndrome in adolescents. Eur J Obstet Gynecol Reprod Biol. 2018 Dec 17;233:114-119 Authors: Bahrami A, Gonoodi K, Khayyatzadeh SS, Tayefi M, Darroudi S, Bahrami-Taghanaki H, Eslami S, Jaberi N, Ferns GA, Farahmand K, Ghyour-Mobarhan M Abstract OBJECTIVE: Premenstrual syndrome (PMS), primary dysmenorrhea (PD), and irritable bowel syndrome (IBS) are common complaints in women of reproductive age. Trace element status may be associated with the development of these disorders but the current data are unclear. The present study focused on the relationship between serum and dietary copper and zinc with some common physical and psychosomatic conditions among young females. STUDY DESIGN: This cross-sectional study comprised 448 adolescent girls who were classified into four groups: individuals with PMS (n = 67), PD (n = 161), both PMS and PD (n = 146), and normal (n = 74). IBS was diagnosed according to the Rome III questionnaire. Flame atomic absorption (Varian AA240FS) was used to measure serum zinc and copper. Food intake of micronutrients was estimated using a three-day dietary record. RESULTS: There was a significant difference in the frequency of IBS across the four corresponding groups as the percentage of subjects. The prevalence of IBS was significantly higher in the PD group [PMS (13.6%), PD (19.9%), both PMS and PD (17.4%) and normal (8.1%); P value < 0.05]. There was no significant differences between the mean values for serum and dietary intake of zinc and copper among four groups (p value > 0.05). Although, the mean dietary zinc intake was significantly lower in subjects with IBS (6.7 ± 2.8 mg/day) versus those without IBS (7.9 ± 3.1 mg/ day, p = 0.032). CONCLUSION: Girls with IBS were found to have significantly higher rates of gynecological symptoms, including PD and PMS. The lower dietary intake of zinc in subjects with IBS indicate a need for greater attention towards dietary patterns in these individuals. PMID: 30590227 [PubMed - as supplied by publisher] View the full article

Twitter-Holidays almost over and time to get back on track? https://t.co/n9fJye4Lsi #FODMAP #IBS #HappyNewYear

Dec 27, 2018
Holidays almost over and time to get back on track? https://www.ibsfree.net/news/2017/12/6/5-reasons-for-a-fodmap-do-over #FODMAP #IBS #HappyNewYear (RSS generated with FetchRss) View the full article

Google-Peppermint oil uses and benefits for beauty, health and home cleanliness - TODAY

Dec 27, 2018
Peppermint oil uses and benefits for beauty, health and home cleanliness TODAYPeppermint may be a sweet holiday treat, but in its essential oil form, it's also a multitasking machine with a plethora of beauty, health and household benefits. View the full article

Google-Helping those struggling with IBS | Contributed Columns - Laramie Boomerang

Dec 27, 2018
Helping those struggling with IBS | Contributed Columns Laramie BoomerangQ: I've been suffering with irritable bowel syndrome (IBS) for a few years now, and often struggle to keep my discomfort under control. What are some ... View the full article

Twitter-When a person describes the feeling of bloating, they may or may not be aware of an increase in abdominal girth. https://t.co/Cc3mdm4T3y #guthealth

Dec 26, 2018
When a person describes the feeling of bloating, they may or may not be aware of an increase in abdominal girth. http://bit.ly/bloatinghelp #guthealth (RSS generated with FetchRss) View the full article

Pubmed-Impact of concomitant dyspepsia and irritable bowel syndrome on symptom burden in patients with gastroesophageal reflux disease.

Dec 26, 2018
Related Articles Impact of concomitant dyspepsia and irritable bowel syndrome on symptom burden in patients with gastroesophageal reflux disease. J Formos Med Assoc. 2018 Dec 21;: Authors: Lei WY, Chang WC, Wen SH, Wong MW, Hung JS, Yi CH, Liu TT, Hsu CS, Orr WC, Vaezi MF, Pace F, Hsieh TC, Chen CL Abstract BACKGROUND: Patients with gastroesophageal reflux disease (GERD) frequently report symptoms like dyspepsia or/and irritable bowel syndrome (IBS). The aim of the study was to investigate the impact of symptom overlap on GERD symptom burden. We also investigate whether GERD overlapping dyspepsia or/and IBS would have different clinical and psychological features as compared with GERD alone. METHODS: A total of 2752 subjects were screened from a health check-up population. We compared the clinical and psychological factors among subjects with GERD alone and with overlap of two or all three diseases. All participants underwent an evaluation with questionnaires including Reflux Disease Questionnaire score, Pittsburgh Sleep Quality Index, Taiwanese Depression Questionnaire, and State-Trait Anxiety Inventory before receiving endoscopic exam. RESULTS: Among the GERD population, we identified 26 with IBS (GERD-IBS), 60 with dyspepsia (GERD-D), and 25 subjects with overlap of all three conditions (GERD-D-IBS). GERD-D and GERD-D-IBS subjects had more severe GERD symptoms as compared subjects with GERD alone (p < 0.001). Subjects with overlapping dyspepsia or/and IBS showed a significant increase in the severity of depression and poorer sleep quality than subjects with GERD alone. Notably, anxiety scores did not differ significantly between subjects with overlapping diseases and GERD alone. CONCLUSION: Our study demonstrates that disease overlap in GERD population is associated with greater symptom burden, higher depression and poorer sleep quality, but not with anxiety. This study highlights the importance of identifying overlapping conditions as a therapeutic strategy for better management of GERD. PMID: 30584006 [PubMed - as supplied by publisher] View the full article

Twitter-A customized, ordinary food-based #diet, called CD-TREAT, has been found to achieve similar effects as #exclusiveenteralnutrition (EEN) in helping #IBD patients with #Crohns achieve remission. Check out the @medpagetoday piece on this @AGA_Gastro

Dec 26, 2018
A customized, ordinary food-based #diet, called CD-TREAT, has been found to achieve similar effects as #exclusiveenteralnutrition (EEN) in helping #IBD patients with #Crohns achieve remission. Check out the @medpagetoday piece on this @AGA_Gastro study: http://ow.ly/YnSR30n4Ssz (RSS generated with FetchRss) View the full article

Google-Pedialyte is targeting the adult holiday hangover market - New York Post

Dec 26, 2018
Pedialyte is targeting the adult holiday hangover market New York Post After years as an semi-underground hangover "cure," the parental staple for fighting infant dehydration is embracing ads targeting adults who indulge in holiday ... View the full article

Google-Survey says constipation disrupts lives of sufferers - WIBW News Now

Dec 26, 2018
Survey says constipation disrupts lives of sufferers WIBW News NowThere are an estimated 35 million people in the United States living with chronic idiopathic constipation. A new survey, Current Insights about Constipation, ... View the full article

Google-Chronic pain, fatigue and mental 'fog' are common symptoms of fibromyalgia - Reno Gazette Journal

Dec 25, 2018
Chronic pain, fatigue and mental 'fog' are common symptoms of fibromyalgia Reno Gazette JournalWhen ongoing pain affects affects both sides of the body, above and below the waist, a fibromyalgia may be to blame. View the full article

Twitter-RT @GIKidsOrg: #Digestivetopic: #Lactose intolerance is when the small #intestine does not make enough of the enzyme lactase needed to brea…

Dec 25, 2018
RT @GIKidsOrg: #Digestivetopic: #Lactose intolerance is when the small #intestine does not make enough of the enzyme lactase needed to brea… (RSS generated with FetchRss) View the full article

Pubmed-Guidelines on the management of irritable bowel syndrome: In memory of Professor Witold Bartnik.

Dec 25, 2018
Related Articles Guidelines on the management of irritable bowel syndrome: In memory of Professor Witold Bartnik. Prz Gastroenterol. 2018;13(4):259-288 Authors: Pietrzak A, Skrzydło-Radomańska B, Mulak A, Lipiński M, Małecka-Panas E, Reguła J, Rydzewska G Abstract These guidelines constitute an update of the previous "Recommendations on the management of irritable bowel syndrome" issued in 2008. They have been developed by a Task Force organized by the Governing Board of the Polish Society of Gastroenterology. They discuss, with particular emphasis on new scientific data covering papers published since 2008, the aetiology, epidemiology, clinical presentation, diagnostic principles and criteria for the diagnosis, and recommendations for the treatment of irritable bowel syndrome (IBS). The English-language acronym for the syndrome (IBS) has become popular in medical and popular scientific language. It is also widely recognized by patients who identify with this diagnosis. Therefore, in the discussed guidelines, this is what we will use. PMID: 30581501 [PubMed] View the full article

Google-Common Reasons behind Rectal Pain (Anal Pain) - Bel Marra Health

Dec 25, 2018
Common Reasons behind Rectal Pain (Anal Pain) Bel Marra HealthThere are many causes of rectal pain, and in this article, we discuss what they are and what causes them. View the full article

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