Antidepressants

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Brand Name Generic name IBS type Type Comments
Celexa® citalopram IBS-C Prescription Selective Serotonin Reuptake Inhibitor (SSRI). May alleviate the abdominal pain and associated symptoms of IBS. Side effect of diarrhea may be helpful for IBS-C.
Cymbalta® duloxetine IBS-A Prescription Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). Helpful for managing pain and maybe for constipation or diarrhea. Effective in treating pain like the TCA's but without the side effects of TCA's.
Desyrel® trazodone IBS-D Prescription Serotonin antagonist and reuptake inhibitor (SARI).
Effexor® venlafaxine IBS-A Prescription Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). Helpful for managing pain and maybe for constipation or diarrhea. Effective in treating pain like the TCA's but without the side effects of TCA's.
Elavil® amitriptyline IBS-D Prescription Tricyclic antidepressant (TCA). Usually recommended when antispasmodic medicines have not been able to control the symptoms of pain and cramping. Common side-effect of constipation can be helpful for IBS-D.
Lexapro® escitalopram IBS-C Prescription Selective Serotonin Reuptake Inhibitor (SSRI). May alleviate the abdominal pain and associated symptoms of IBS. Side effect of diarrhea may be helpful for IBS-C.
Norpramin® / Pertofrane® desipramine IBS-D Prescription Tricyclic antidepressant (TCA). Usually recommended when antispasmodic medicines have not been able to control the symptoms of pain and cramping. Common side-effect of constipation can be helpful for IBS-D. Less unwanted side-effects than Elavil®.
Pamelor® / Aventyl® nortriptyline IBS-D Prescription Tricyclic antidepressant (TCA). Usually recommended when antispasmodic medicines have not been able to control the symptoms of pain and cramping. Common side-effect of constipation can be helpful for IBS-D. Less unwanted side-effects than Elavil®.
Paxil® paroxetine IBS-C Prescription Selective Serotonin Reuptake Inhibitor (SSRI). May alleviate the abdominal pain and associated symptoms of IBS. Side effect of diarrhea may be helpful for IBS-C.
Pristiq® desvenlafaxine IBS-A Prescription Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). Helpful for managing pain and maybe for constipation or diarrhea. Effective in treating pain like the TCA's but without the side effects of TCA's.
Prozac® fluoxetine IBS-C Prescription Selective Serotonin Reuptake Inhibitor (SSRI). May alleviate the abdominal pain and associated symptoms of IBS. Side effect of diarrhea may be helpful for IBS-C.
Remeron® mirtazapine IBS-D Prescription Noradrenergic and specific serotonergic antidepressant (NaSSA). Can also be classified as a tetracyclic antidepressant (TeCA).
Savella® milnacipram IBS-A Prescription Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). Helpful for managing pain and maybe for constipation or diarrhea. Effective in treating pain like the TCA's but without the side effects of TCA's.
Tofranil® imipramine IBS-D Prescription Tricyclic antidepressant (TCA). Usually recommended when antispasmodic medicines have not been able to control the symptoms of pain and cramping. Common side-effect of constipation can be helpful for IBS-D.
Wellbutrin® / Zyban® bupropion IBS-D Prescription Norepinephrine-dopamine reuptake inhibitor (NDRI).
Zoloft® sertraline IBS-C Prescription Selective Serotonin Reuptake Inhibitor (SSRI). May alleviate the abdominal pain and associated symptoms of IBS. Side effect of diarrhea may be helpful for IBS-C.